Evidence map›Paper›PMID 35127485›Full record

ArticleFrontiers in oncology2021

Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis.

Selma Olsson Åkefeldt, Mohamad Bachar Ismail, Alexandre Belot, Giulia Salvatore, Nathalie Bissay, Désirée Gavhed, Maurizio Aricò, Jan-Inge Henter, Hélène Valentin, Christine Delprat

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Selma Olsson ÅkefeldtChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Mohamad Bachar IsmailUnivLyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
Alexandre BelotUnivLyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
Giulia SalvatoreUnivLyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
Nathalie BissayUnivLyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
Désirée GavhedChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Maurizio AricòPediatrics, Azienda Sanitaria Locale, Pescara, Italy.
Jan-Inge HenterChildhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Hélène ValentinCentre de Recherche en Cancérologie de Lyon (CRCL) - INSERM U1052 - CNRS UMR5286 - Centre Léon Bérard, Lyon, France.
Christine DelpratUnivLyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
Karolinska University Hospital · SEUniversité Claude Bernard Lyon 1 · FRASL Roma · ITCentre de Recherche en Cancérologie de Lyon · FRCentre International de Recherche en Infectiologie · FRInserm · FRKarolinska Institutet · SEThe Lymphoma Academic Research Organisation · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm characterised by the accumulation into granulomas of apoptosis-resistant pathological dendritic cells (LCH-DCs). LCH outcome ranges from self-resolving to fatal. Having previously shown that, (

Indexed as

biotherapy and chemotherapycytokinedendritic cellsinterleukin-17A (IL-17A)langerhans cell histiocytosis (LCH)survivalvinblastine

Identifiers

PMID35127485
PMCPMC8814633
OpenAlexW4206968557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.