Evidence map›Paper›PMID 35127212›Full record

ArticleSurgical neurology international2022

Unraveling a rare cause of spinal stenosis: Coexistent AL and ATTR amyloidosis involving the ligamentum flavum.

Amandeep Godara, Andy Y Wang, Knarik Arkun, Teresa Fogaren, Adnan S Qamar, Ellen D McPhail, James Kryzanski, Ron Riesenburger, Raymond Comenzo

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical neurology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Amandeep GodaraDepartment of Hematology and Hematologic Malignancies, University of Utah, Salt Lake, Utah.
Andy Y WangDepartment of Neurosurgery, Tufts Medical Center, Washington, Boston, United States.
Knarik ArkunDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, Washington, Boston, United States.
Teresa FogarenDepartment of John Conant Davis Myeloma and Amyloid Program, Tufts Medical Center, Washington, Boston, United States.
Adnan S QamarDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, Washington, Boston, United States.
Ellen D McPhailDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, New York, United States.
James KryzanskiDepartment of Neurosurgery, Tufts Medical Center, Washington, Boston, United States.
Ron RiesenburgerDepartment of Neurosurgery, Tufts Medical Center, Washington, Boston, United States.
Raymond ComenzoDepartment of John Conant Davis Myeloma and Amyloid Program, Tufts Medical Center, Washington, Boston, United States.
University of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmyloidosis is a protein misfolding disorder that leads to the deposition of beta-pleated sheets of a fibrillar derivative of various protein precursors. Identification of the type of precursor protein is integral in treatment decision-making. The presence of two different types of amyloid in the same patient is unusually rare, and there are no previous reports of two different types of amyloid deposition in the ligamentum flavum (LF) in the same patient. CASE DESCRIPTION: Here, we describe two patients with spinal stenosis who underwent laminectomies and were found to have AL and ATTR amyloid deposits in the LF.

conclusionAs the spine is becoming recognized as a site for ATTRwt amyloid deposition, patients undergoing spinal decompression surgery may potentially benefit from evaluation for amyloidosis in the LF.

Indexed as

Ligamentum flavumLight chainSpinal stenosisWild-type transthyretin amyloid

Identifiers

PMID35127212
PMCPMC8813631
OpenAlexW4205527236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.