Evidence map›Paper›PMID 35127174›Full record

ReviewJournal of advanced research2022

Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures.

Nazeer Hussain Khan, Maria Mir, Lei Qian, Mahnoor Baloch, Muhammad Farhan Ali Khan, Asim-Ur- Rehman, Ebenezeri Erasto Ngowi, Dong-Dong Wu, Xin-Ying Ji

Open access · goldAbstract readReview
In one paragraph

Review in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 200 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Nazeer Hussain KhanHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Maria MirDepartment of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Lei QianHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Mahnoor BalochSchool of Natural Sciences, National University of Science and Technology, Islamabad 44000, Pakistan.
Muhammad Farhan Ali KhanDepartment of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Asim-Ur- RehmanDepartment of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Ebenezeri Erasto NgowiHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Dong-Dong WuHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Xin-Ying JiHenan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China.
Henan University · CNQuaid-i-Azam University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion. Based on the rapid prevalence of skin cancers, and lack of efficient drug delivery systems, it is essential to surge the possible ways to prevent or cure the disease. Aim of review: Although surgical modalities and therapies have been made great progress in recent years, however, there is still an urgent need to alleviate its increased burden. Hence, understanding the precise pathophysiological signaling mechanisms and all other factors of such skin insults will be beneficial for the development of more efficient therapies. Key scientific concepts of review: In this review, we explained new understandings about onset and development of skin cancer and described its management via polymeric micro/nano carriers-based therapies, highlighting the current key bottlenecks and future prospective in this field. In therapeutic drug/gene delivery approaches, polymeric carriers-based system is the most promising strategy. This review discusses that how polymers have successfully been exploited for development of micro/nanosized systems for efficient delivery of anticancer genes and drugs overcoming all the barriers and limitations associated with available conventional therapies. In addition to drug/gene delivery, intelligent polymeric nanocarriers platforms have also been established for combination anticancer therapies including photodynamic and photothermal, and for theranostic applications. This portfolio of latest approaches could promote the blooming growth of research and their clinical availability.

Indexed as

NanostructuresSkin NeoplasmsBiologyDrug Delivery SystemsHumansPolyethylene GlycolsPolymersPolyethylene GlycolsPolymers5-ALA, 5-aminolevulinic acid5-FU, 5-fluorouracilAIDS, Acquired immune deficiency syndromeBasal cell carcinomaBCC, Basal cell carcinomaBCCs, Basal cell carcinomascAMP, Cyclic adenosine monophosphateCREB, response element-binding proteinDDS, Drug delivery systemDIM-D, Di indolyl methane derivativedPG, Dendritic polyglycerolDrug deliveryGd, GadoliniumGene deliveryGNR-PEG-MN, PEGylated gold nanorod microneedleHH, HedgehogHPMC, Hydroxypropyl methylcellulosehTERT, Human telomerase reverse transcriptaseIPM, Isopropyl myristateMCIR, Melanocortin-1 receptorMicroneedlesMn, ManganeseMNPs, Magnetic nanoparticleMNs, MicroneedlesMRI, Magnetic Resonance ImagingMSC, Melanoma skin cancerNMSC, Non melanoma skin cancerNPs, Nano ParticlesOTR, Organ transplant recipientsPAMAM, Poly-amidoaminesPAN, PolyacrylonitrilePATCH1, PatchPCL, Poly (ε-caprolactone)PDT, Photodynamic therapyPEG, Polyethylene glycolPLA-HPG, Poly (d-l-lactic acid)-hyperbranched polyglycerolPLA, Poly lactic acidPLGA, Poly (lactide-co-glycolide) copolymersPLL, Poly (L-lysine)Polymeric nanocarriersQDs, Quantum dotsSCC, Squamous cell CarcinomaSC, Skin cancerSMO, SmoothenSPIO, Superparamagnetic iron oxideSquamous cell carcinomaUV, Ultra Violet

Identifiers

PMID35127174
PMCPMC8799916
OpenAlexW3174972843

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.