Evidence map›Paper›PMID 35127167›Full record

ArticleJournal of advanced research2022

The therapeutic effect of IL-21 combined with IFN-γ inducing CD4

Changlin Zhao, Xianlin Wu, Jia Chen, Guoqiang Qian

Open access · goldAbstract read
In one paragraph

Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. C-X-C chemokine receptor type 5World journal of gastroenterology · 2025
    Trial
  2. Article
  3. Article
  4. Foods (Basel, Switzerland) · 2024
    Article
  5. Integrating multi-omics techniques andFrontiers in immunology · 2024
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Changlin ZhaoSchool of Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.
Xianlin WuThe First Affiliated Hospital, Jinan University, Guangzhou 510632,China.
Jia ChenSchool of Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.
Guoqiang QianSchool of Health, Guangdong Pharmaceutical University, Guangzhou 510310, China.
Guangdong Pharmaceutical University · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Liver cancer is a malignant tumor with high incidence and short survival time. In order to increase the cure rate and disease-free survival rate of liver cancer, it is necessary to seek effective treatment methods. Objectives: The objective of this study is to evaluate the therapeutic effects of IL-21 and IFN-γ inducing the formation of CD4 Methods: The methods of analyze the relationship between CD4 Results: The study found that the number of CD4 Conclusion: The conclusion of the study is that IL-21 combined with IFN-γ induces stem cells to differentiate into CD4

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsHumansInterleukin-21InterleukinsMiceReceptors, CXCR5Tumor MicroenvironmentCXCR5 protein, humanInterleukin-21InterleukinsReceptors, CXCR5CD4+CXCR5+CD57+T cellsHepatocellular carcinomaIFN-γIL-21TregTumor microenvironment

Identifiers

PMID35127167
PMCPMC8799868
OpenAlexW3172565286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.