Evidence map›Paper›PMID 35127105›Full record

ArticleCanadian journal of kidney health and disease2022

Deriving Normative Data on 24-Hour Ambulatory Blood Pressure Monitoring for South Asian Children (ASHA): A Clinical Research Protocol.

Samina Nazarali, Cal H Robinson, Farah Khan, Tayler Pocsai, Dipika Desai, Russell J De Souza, Girish Bhatt, Allison Dart, Janis Dionne, Salma Elmansy and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of kidney health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 2 countries.

Samina NazaraliMichael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Cal H RobinsonDivision of Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-2223-0646
Farah KhanPopulation Health Research Institute, Hamilton, ON, Canada.
Tayler PocsaiPopulation Health Research Institute, Hamilton, ON, Canada.
Dipika DesaiPopulation Health Research Institute, Hamilton, ON, Canada.
Russell J De SouzaPopulation Health Research Institute, Hamilton, ON, Canada.
Girish BhattDepartment of Pediatrics, All India Institute of Medical Sciences, Bhopal, India.
Allison DartDivision of Nephrology, Department of Pediatrics, University of Manitoba, Winnipeg, Canada.ORCID https://orcid.org/0000-0002-4718-9408
Janis DionneDivision of Nephrology, Department of Pediatrics, BC Children's Hospital, The University of British Columbia, Vancouver, Canada.
Salma ElmansyDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Sujane KandasamyDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Scott A LearSimon Fraser University, Burnaby, BC, Canada.
Joyce ObeidDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Rulan ParekhDivision of Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Zubin PunthakeePopulation Health Research Institute, Hamilton, ON, Canada.
Rajiv SinhaPediatric Nephrology, Department of Pediatrics, Institute of Child Health, Kolkata, India.
Lehana ThabaneDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Gita WahiDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Michael ZappitelliDivision of Nephrology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.
Sonia S AnandPopulation Health Research Institute, Hamilton, ON, Canada.
Rahul ChanchlaniDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Population Health Research Institute · CAMcMaster University · CAHospital for Sick Children · CAImpact · CAAll India Institute of Medical Sciences Bhopal · INInstitute of Child Health · INSimon Fraser University · CAUniversity of British Columbia · CAUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe global prevalence of hypertension in children and adolescents has increased over the past 2 decades and is the strongest predictor of adult hypertension. South Asians have an increased prevalence of metabolic syndrome associated risk factors including abdominal obesity, diabetes, and hypertension. All these factors contribute to their increased cardiovascular disease burden. Accurate and early identification of hypertension in South Asian children is a necessary aspect of cardiovascular disease prevention. Ambulatory blood pressure monitoring (ABPM) is considered the gold-standard for pediatric blood pressure (BP) measurement. However, its utilization is limited due to the lack of validated normative reference data in diverse, multiethnic pediatric populations.

objectiveThe primary objective is to establish normative height-sex and age-sex-specific reference values for 24-h ABPM measurements among South Asian children and adolescents (aged 5-17 years) in Ontario and British Columbia, Canada. Secondary objectives are to evaluate differences in ABPM measurements by body mass index classification, to compare our normative data against pre-existing data from German and Hong Kong cohorts, and to evaluate relationships between habitual movement behaviors, diet quality, and ABPM measurements.

designCross-sectional study, quasi-representative sample.

settingParticipants will be recruited from schools, community centers, and places of worship in Southern Ontario (Greater Toronto and Hamilton area, including the Peel Region) and Greater Vancouver, British Columbia.

participantsWe aim to recruit 2113 nonoverweight children (aged 5-17 years) for the primary objective. We aim to recruit an additional 633 overweight or obese children to address the secondary objectives. MEASUREMENTS: Ambulatory BP monitoring measurements will be obtained using Spacelabs 90217 ABPM devices, which are validated for pediatric use. The ActiGraph GT3X-BT accelerometer, which has also been validated for pediatric use, will be used to obtain movement behavior data.

methodsFollowing recruitment, eligible children will be fitted with 24-h ABPM and physical activity monitors. Body anthropometrics and questionnaire data regarding medical and family history, medications, diet, physical activity, and substance use will be collected. Ambulatory BP monitoring data will be used to develop height-sex- and age-sex-specific normative reference values for South Asian children. Secondary objectives include evaluating differences in ABPM measures between normal weight, overweight and obese children; and comparing our South Asian ABPM data to existing German and Hong Kong data. We will also use compositional data analysis to evaluate associations between a child's habitual movement behaviors and ABPM measures. LIMITATIONS: Bloodwork will not be performed to facilitate recruitment. A non-South Asian comparator cohort will not be included due to feasibility concerns. Using a convenience sampling approach introduces the potential for selection bias.

conclusionsAmbulatory BP monitoring is a valuable tool for the identification and follow-up of pediatric hypertension and overcomes many of the limitations of office-based BP measurement. The development of normative ABPM data specific to South Asian children will increase the accuracy of BP measurement and hypertension identification in this at-risk population, providing an additional strategy for primary prevention of cardiovascular disease.

Indexed as

ambulatory blood pressure monitoringblood pressurechildrenhypertensionpediatricSouth Asian

Identifiers

PMID35127105
PMCPMC8808039
OpenAlexW4210692243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.