ArticleTherapeutic advances in infectious disease
Evaluation of step-down oral antibiotic therapy for uncomplicated streptococcal bloodstream infections on clinical outcomes.
Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- The effectiveness of intravenous (IV) to oral (PO) antibiotic switch (IVOS) interventions in managing community- and hospital-acquired pneumonia-a systematic review.JAC-antimicrobial resistance · 2026Review
- Oral switch antibiotic therapy in uncomplicatedJAC-antimicrobial resistance · 2025Article
- Oral antibiotic stepdown therapy for uncomplicated streptococcal bloodstream infections.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Short versus long treatment duration for streptococcal bloodstream infection.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Comparison of intravenous vs intravenous with step-down to oral antibiotic treatment course for Streptococcus and Enterococcus bloodstream infections.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- A Multicenter Retrospective Study Evaluating Intravenous to Oral Antibiotic Stepdown for Uncomplicated Streptococcal Bacteremia.Open forum infectious diseases · 2024Article
- Review
- Fever and infections in surgical intensive care: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document.Trauma surgery & acute care open · 2024Article
- Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives.Microorganisms · 2023Review
- Intravenous versus Partial Oral Antibiotic Therapy in the Treatment of Uncomplicated Bloodstream Infection Due toMicroorganisms · 2023Article
- Comparison of Oral and Intravenous Definitive Antibiotic Therapy for Beta-Hemolytic Streptococcus Species Bloodstream Infections from Soft Tissue Sources: a Propensity Score-Matched Analysis.Antimicrobial agents and chemotherapy · 2023Article
- In vitro activity of sulopenem and comparator agents against Enterobacterales and anaerobic clinical isolates collected during the SENTRY Antimicrobial Surveillance Program.The Journal of antimicrobial chemotherapy · 2023Article
- Uncomplicated Streptococcal Bacteremia: The Era of Oral Antibiotic Step-down Therapy?International journal of antimicrobial agents · 2023Article
- Antibiotic prescribing for adults with group A streptococcal bacteremia in a large healthcare system.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Impact of specialty on the self-reported practice of using oral antibiotic therapy for definitive treatment of bloodstream infections.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the severity and frequency of streptococcal bloodstream infections (BSIs), the effectiveness of oral definitive therapy remains unknown. The objective of this study was to evaluate the clinical outcomes of step-down oral antibiotics for the treatment of uncomplicated streptococcal BSIs.
methodsIn this retrospective cohort study, adult patients admitted with uncomplicated streptococcal BSI between June 2015 and June 2017 were included. Patients were excluded if they received <48 h of antibiotic therapy; therapy was started >48 h after first positive culture; had complicated infections of endocarditis, bone and joint infections, or central nervous system infections; Pitt bacteremia score (PBS) ⩾ 4; or failed to respond to effective therapy necessitating continued intravenous (IV) therapy. Patients were grouped by receipt of step-down oral antibiotic therapy (PO group)
resultsOf 244 patients included, 40% received step-down oral therapy (
conclusionIn uncomplicated streptococcal BSI, patients treated with step-down oral antibiotic therapy had significantly shorter LOS compared with continued IV therapy without compromise of clinical outcomes.
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