Evidence map›Paper›PMID 35126958›Full record

ArticleJournal of healthcare engineering2022

LncRNA MAGI2-As3 Suppresses the Proliferation and Invasion of Cervical Cancer by Sponging MiR-15b.

Yiqing Chai, Lili Wang, Yanwen Qu, Zhixia Hu

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of healthcare engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Yiqing ChaiDepartment of Ultrasound, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300000, China.
Lili WangDepartment of Gynaecology and Obstetrics, Rizhao Hospital of TCM, Rizhao 276800, Shandong, China.
Yanwen QuDepartment of Gynecological Oncology, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao 266000, China.
Zhixia HuDepartment of Prices and Charges Management Division, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China.ORCID 0000-0001-7035-9033
People’s Hospital of Rizhao · CNQingdao University · CNShandong Provincial Hospital · CNTianjin Central Hospital of Gynecology Obstetrics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical cancer is the leading cause of cancer deaths among women, and more than 85% of cervical cancer deaths occur in low and middle-income countries. The purpose of this study is to investigate the functions of MAGI2-AS3 and miR-15b in cervical cancer. MATERIALS AND

methodsThe mRNA levels of MAGI2-AS3, miR-15b, and CCNE1 were evaluated using RT-qPCR assay. Dual-luciferase reporter gene assay was used to confirm whether miR-15b binds to CCNE1.

resultsLncRNA MAGI2-AS3 was downregulated, while miR-15b was upregulated in cervical cancer. Cervical cancer patients with low expression of MAGI2-AS3 have a poor prognosis. Upregulation of MAGI2-AS3 inhibited proliferative and invasive abilities of HeLa cells via regulating the expression of miRNA-15b. MiR-15b inhibitor suppressed cell proliferation and invasion. CCNE1 was a direct target gene of miR-15b, which binds to the 3'-UTR of its mRNA. MiR-15b partially reversed the inhibitory effect of overexpression of MAGI2-AS3 on the proliferation and invasion of HeLa cells. MAGI2-AS3 mediated the expression of CCNE1 in HeLa cells.

conclusionLncRNA MAGI2-AS3 inhibits the proliferation and invasion of cervical cancer cells via the miRNA-15/CCNE1 axis. Our results illustrates that MAGI2-AS3 can be used as a useful clinical predictor for early diagnosis and prognosis assessment of cervical cancer.

Indexed as

MicroRNAsRNA, Long NoncodingUterine Cervical NeoplasmsAdaptor Proteins, Signal TransducingCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticGuanylate KinasesHeLa CellsHumansRNA, MessengerAdaptor Proteins, Signal TransducingGuanylate KinasesMAGI2 protein, humanMicroRNAsMIRN15 microRNA, humanRNA, Long NoncodingRNA, Messenger

Identifiers

PMID35126958
PMCPMC8808199
OpenAlexW4210281136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.