Evidence map›Paper›PMID 35126820›Full record

ArticleOxidative medicine and cellular longevity2022

miR-154-5p Affects the TGF

Che Bian, Zhilin Luan, Haibo Zhang, Ruijing Zhang, Jing Gao, Yuxia Wang, Jia Li, Huiwen Ren

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Research progress on the regulation of miRNAs in diabetic kidney disease and osteoporosis.International journal of clinical and experimental pathology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Crosstalk of ubiquitin system and non-coding RNA in fibrosis.International journal of biological sciences · 2024
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Che BianDepartment of Endocrinology and Metabolism, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0003-2258-4257
Zhilin LuanAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.ORCID https://orcid.org/0000-0003-0774-4718
Haibo ZhangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.ORCID https://orcid.org/0000-0003-1755-1813
Ruijing ZhangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.ORCID https://orcid.org/0000-0002-0044-1573
Jing GaoDepartment of Gerontology, Xin Hua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-8797-9933
Yuxia WangDepartment of Endocrinology and Metabolism, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0002-6981-0525
Jia LiDepartment of Endocrinology and Metabolism, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0001-5400-0610
Huiwen RenAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.ORCID https://orcid.org/0000-0002-6037-8561
Dalian Medical University · CNFourth Affiliated Hospital of China Medical University · CNXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe study is aimed at verifying miR-154-5p and Smurf1 combination in glomerular mesangial cells regulating TGF

methodsThe diabetic SD rat model and high-glucose-cultured primary mesangial cells and cell lines were established. miR-154-5p mimic and inhibitor, Smurf1 siRNA, and TGF

resultsmiR-154-5p was significantly increased and mainly concentrated in the glomerular of renal cortex in well-established diabetic rat renal tissues. Rno-miR-154-5p combined Rno-Smurf1 3' UTR, while Smurf1 combined Smad3 directly. Meanwhile, miR-154-5p regulates TGF

conclusionmiR-154-5p regulates the TGF

Indexed as

Signal TransductionAnimalsAntagomirsCell ProliferationDiabetes Mellitus, ExperimentalDiabetic NephropathiesFibrosisKidneyMaleMesangial CellsMicroRNAsProtein BindingRatsRats, Sprague-DawleyRNA InterferenceRNA, Small InterferingAntagomirsMicroRNAsMIRN154 microRNA, ratRNA, Small InterferingSmad3 ProteinSmurf1 protein, ratTransforming Growth Factor beta1Ubiquitin-Protein Ligases

Identifiers

PMID35126820
PMCPMC8814716
OpenAlexW4210636124

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.