ArticlePain research & management2022
Decreased Gray Matter Volume in the Frontal Cortex of Migraine Patients with Associated Functional Connectivity Alterations: A VBM and rs-FC Study.
Article in Pain research & management, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Resting-state fMRI correlates of acupuncture in migraine: a coordinate-based meta-analysis.Journal of oral & facial pain and headache · 2026Pooled it
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.Brain : a journal of neurology · 2026Review
- Differences in Brain Structure and Functional Connectivity During Memory Processing in Posttraumatic Stress Disorder.Psychiatry investigation · 2026Article
- Altered functional connectivity density in the prefrontal-limbic-visual networks of vestibular migraine.Scientific reports · 2026Article
- Altered Topology of Brain Structural Network in Patients With Migraine Without Aura: A Structural MRI Study.European journal of pain (London, England) · 2025Article
- Effect of auricular pressure bean combined with wrist-ankle needle on cognitive function and prognosis in migraine patients with anxiety and depression disorders.American journal of translational research · 2025Article
- Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis.Frontiers in neuroscience · 2023Review
- The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- The brain structure and function abnormalities of migraineurs: A systematic review and neuroimaging meta-analysis.Frontiers in neurology · 2022Review
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundResting-state functional MRI is widely used in migraine research. However, the pathophysiology and imaging markers specific for migraine pathologies are not well understood. In this study, we combined both structural and functional images to explore the concurrence and process of migraines.
methodsThirty-four patients with a history of migraine without aura presenting during the interictal period (MwoA-DI), 10 patients with migraine without aura presenting during the acute attack (MwoA-DA), and 32 healthy controls (HCs) were recruited in this study. All participants underwent scanning via MRI. Voxel-based morphometry (VBM) and seed-based resting-state functional connectivity (rs-FC) analysis were used to detect the brain structural and associated brain functional connectivity.
resultsIn VBM analysis, a decrease of gray matter volume (GMV) in the middle frontal cortex was found in MwoA patients compared with HCs. The GMV of the middle frontal cortex had a negative correction with the duration of disease. In rs-FC analysis, the left middle frontal cortex (lower, VBM result) in both the MwoA-DA and the HC groups showed significantly increased functional connectivity with the left middle frontal cortex (upper) and left superior frontal cortex compared with MwoA-DI. The left middle frontal cortex (lower) in the MwoA-DI group also showed decreased functional connectivity in the left posterior cingulate cortex (PCC) compared with the HC group. The left middle frontal cortex (lower) in the MwoA-DA group demonstrated significantly increased functional connectivity in the left cerebellum lobule VI compared with the HC group.
conclusionsOur results demonstrated that the middle frontal cortex may serve as an important target in the frequency and severity of migraines due to its role in pain regulation through the default mode network, especially in the PCC. In addition, the cerebellum may modulate the pathophysiology of migraines by serving as a communication point between the cortex and the brainstem.
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