ArticleEvolutionary applications2022
Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo.
Article in Evolutionary applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Identifying Transgenic Approaches to Mitigate Vector Transmission of Malaria by Anopheles gambiae.Cureus · 2026Review
- Exploratory conversations with biodiversity-oriented civil society groups on the potential applications of gene drive-modified mosquitoes for malaria control in Tanzania.Transgenic research · 2026Article
- "Have Scientists Done Enough?" Community Perspectives on Gene Drive-Modified Mosquitoes for Malaria Control in Northern Uganda: A Mixed-Methods Study.Journal of epidemiology and global health · 2025Article
- The potential of gene drives in malaria vector species to control malaria in African environments.Nature communications · 2024Article
- Assessing CRISPR/Cas9 potential in SDG3 attainment: malaria elimination-regulatory and community engagement landscape.Malaria journal · 2024Review
- Navigating biosafety regulatory frameworks for genetic engineering in Africa: a focus on genome editing and gene drive technologies.Frontiers in bioengineering and biotechnology · 2024Article
- Regulatory and policy considerations for the implementation of gene drive-modified mosquitoes to prevent malaria transmission.Transgenic research · 2023Review
- The Promise and Challenge of Genetic Biocontrol Approaches for Malaria Elimination.Tropical medicine and infectious disease · 2023Review
- Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study.Malaria journal · 2022Article
- The importance of effective data sharing and reuse to funders and others supporting research.Learned publishing : journal of the Association of Learned and Professional Society Publishers · 2022Article
- Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo.Evolutionary applications · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Malaria elimination will be challenging in countries that currently continue to bear high malaria burden. Sex-ratio-distorting gene drives, such as driving-Y, could play a role in an integrated elimination strategy if they can effectively suppress vector populations. Using a spatially explicit, agent-based model of malaria transmission in eight provinces spanning the range of transmission intensities across the Democratic Republic of the Congo, we predict the impact and cost-effectiveness of integrating driving-Y gene drive mosquitoes in malaria elimination strategies that include existing interventions such as insecticide-treated nets and case management of symptomatic malaria. Gene drive mosquitoes could eliminate malaria and were the most cost-effective intervention overall if the drive component was highly effective with at least 95% X-shredder efficiency at relatively low fertility cost, and associated cost of deployment below 7.17 $int per person per year. Suppression gene drive could be a cost-effective supplemental intervention for malaria elimination, but tight constraints on drive effectiveness and cost ceilings may limit its feasibility.
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