ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2021
Role of pregnancy-associated plasma protein A (PAPP-A) and human-derived chorionic gonadotrophic hormone (free β-hCG) serum levels as a marker in predicting of Small for gestational age (SGA): A cohort study.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- PAPPA's role in female reproduction.Reproduction (Cambridge, England) · 2025Review
- Study of first-trimester serum levels of β-hCG and PAPP-A as a screening test for fetal development of intrauterine growth restriction.BMC pregnancy and childbirth · 2025Article
- Relationship Between PAPP-A Levels in the First Trimester of Pregnancy and Complication Risk.International journal of women's health · 2025Article
- The Association and diagnostic value between Maternal Serum Placental Markers and Placenta Previa.European journal of obstetrics & gynecology and reproductive biology: X · 2024Article
- First trimester maternal serum PAPP-A and free β-hCG levels and risk of SGA or LGA in women with and without GDM.BMC pregnancy and childbirth · 2024Article
- Clinical value of prenatal screening markers in early pregnancy combined with perinatal characteristics to predict fetal growth restriction.Translational pediatrics · 2024Article
- Review
- Role of First Trimester Screening Biochemical Markers to Predict Hypertensive Pregnancy Disorders and SGA Neonates-A Narrative Review.Healthcare (Basel, Switzerland) · 2023Review
- Fetal Growth Restriction Is Associated with Pregnancy Associated Plasma Protein A and Uterine Artery Doppler in First Trimester.Journal of clinical medicine · 2023Article
- Relationship between False Positive Screening Results of Down Syndrome and Adverse Pregnancy Outcomes.Iranian journal of nursing and midwifery researchArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmall-for-gestational-age (SGA) is one of the most important conditions, which is associated with the risk of perinatal mortality and morbidity. The levels of pregnancy-associated plasma protein A (PAPP-A) and β-human-derived chorionic gonadotrophic (β-hCG) in the first trimester can predict this adverse outcome, considering the controversial nature of studies in this area, this cohort study was conducted to investigate the role of PAPP-A and freeβ-hCG levels for predicting SGA. MATERIALS AND
methodsIn this cohort study, from 16 randomly selected health centers in Isfahan, Iran, 4605 volunteer pregnant women who had performed first-trimester fetal anomalies screening tests were chosen based on the census, from July 2016 to June 2018. The multiples of the median (MoM) PAPP-A <0.4 and MoM β-hCG >3 were considered as abnormal; the samples were followed up after childbirth. The biomarkers' serum levels, relative risk, and odds ratio (OR) of SGA were compared in both SGA and appropriate for gestational age (AGA) groups.
resultsIn the SGA group, the mean of MOM PAPP-A was significantly lower (0.96 vs. 1.1 with
conclusionThe results of the study showed that the low levels of PAPP-A would cause 3.213 times increase in the chance of developing SGA and no association between high level of βhCG >3 with SGA. Therefore, low level of the PAPP-A is a warning indicator for SGA.
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