Evidence map›Paper›PMID 35126370›Full record

ArticleFrontiers in immunology2021

Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis.

Jie Jiang, Xinli Zhan, Tuo Liang, Liyi Chen, Shengsheng Huang, Xuhua Sun, Wenyong Jiang, Jiarui Chen, Tianyou Chen, Hao Li and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jie JiangThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xinli ZhanThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Tuo LiangThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Liyi ChenThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shengsheng HuangThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xuhua SunThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wenyong JiangThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jiarui ChenThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Tianyou ChenThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hao LiThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yuanlin YaoThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Shaofeng WuThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jichong ZhuThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
Chong LiuThe First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.
First Affiliated Hospital of GuangXi Medical University · CNGuangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis. Materials and Methods: The protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis. Results: SAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity. Conclusion: Dysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis.

Indexed as

Computational BiologyDisease SusceptibilityFemur Head NecrosisGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMonocytesProtein Interaction MappingProtein Interaction MapsSerum Amyloid A ProteinSpondylitis, AnkylosingTubulinSAA1 protein, humanSerum Amyloid A ProteinTUBA8 protein, humanTubulinankylosing spondylitisdrug sensitivity analysisfemoral head necrosisimmune cell composition analysisimmune cell infiltrationprotein park analysisroutine blood testsweighted gene co-expression network analysis

Identifiers

PMID35126370
PMCPMC8812255
OpenAlexW4206038222

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.