Evidence map›Paper›PMID 35126361›Full record

ArticleFrontiers in immunology2021

Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus

Yuyuan Ma, Junting Jia, Rui Fan, Ying Lu, Xiong Zhao, Yadi Zhong, Jierong Yang, Limin Ma, Yanlin Wang, Maomin Lv and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Yuyuan MaNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Junting JiaNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Rui FanNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Ying LuShenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Institute of Translational Medicine, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xiong ZhaoNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Yadi ZhongNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Jierong YangResearch and Development Department, Grand Life Science and Technology. Ltd., Beijing, China.
Limin MaNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Yanlin WangNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Maomin LvNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Haiyuan YangDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, China.
Lisha MouShenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Institute of Translational Medicine, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Yifan DaiDepartment of Medical Genetics, School of Basic Medical Science, Nanjing Medical University, Nanjing, China.
Shutang FengResearch and Development Department, Grand Life Science and Technology. Ltd., Beijing, China.
Jingang ZhangNational Medical Products Administration (NMPA) Key Laboratory for Quality Control of Blood Products, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Academy of Military Medical Sciences · CNNational Medical Products Administration · CNNanjing Medical University · CNShenzhen Second People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pig to human xenotransplantation is considered to be a possible approach to alleviate the shortage of human allografts. Porcine endogenous retrovirus (PERV) is the most significant pathogen in xenotransplantation. We screened for pigs that consistently did not transmit human-tropic replication competent PERVs (HTRC PERVs), namely, non-transmitting pigs. Then, we conducted whole-genome resequencing and full-length transcriptome sequencing to further investigate the sequence characteristics of one non-transmitting pig. Using

Indexed as

Amino Acid SequenceAnimalsCell LineCells, CulturedChinaEndogenous RetrovirusesGene Expression ProfilingGene Products, polGenes, polGenomeGenome, ViralHEK293 CellsHumansProvirusesSequence Homology, Amino AcidSwineGene Products, polChinese miniature pigdefective genefull-length transcriptome sequencinginbreedingporcine endogenous retroviruswhole-genome resequencing

Identifiers

PMID35126361
PMCPMC8807647
OpenAlexW4206258468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.