Evidence map›Paper›PMID 35126303›Full record

ArticleFrontiers in neurology2021

The Alteration of Circulating Lymphocyte Subsets During Tacrolimus Therapy in Neuromyelitis Optica Spectrum Disorder and Its Correlation With Clinical Outcomes.

Liang Wang, Wenjuan Huang, Jingzi ZhangBao, Xuechun Chang, Hongmei Tan, Lei Zhou, Chuanzhen Lu, Min Wang, Jiahong Lu, Chongbo Zhao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Liang WangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Wenjuan HuangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Jingzi ZhangBaoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Xuechun ChangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Hongmei TanDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Lei ZhouDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Chuanzhen LuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Min WangDepartment of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China.
Jiahong LuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Chongbo ZhaoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Chao QuanDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Fudan University · CNHuashan Hospital · CNEye & ENT Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to explore the alteration of circulating lymphocyte subsets before and after tacrolimus (TAC) therapy in neuromyelitis optica spectrum disorder (NMOSD) and its correlation with clinical outcomes.

methodsAnti-aquaporin-4 antibody (AQP4-ab)-positive patients with NMOSD treated with TAC were followed and clinically evaluated at 0, 3, 6, and 12 months after initiation of TAC. Flow cytometry was employed to detect the proportion of various whole blood lymphocyte subsets at every time point. Correlation analysis was further performed to explore the association between annualized relapse rate (ARR), the Expanded Disability Status Scale (EDSS) score, and the proportion of circulating lymphocyte subsets before and after TAC therapy.

resultsA total of 13 eligible patients with NMOSD were included. The proportion of CD19

conclusionPossibly through increasing regulatory B and suppressing BAFFR

Indexed as

clinical outcomecorrelationlymphocyte subsetneuromyelitis optica spectrum disordertacrolimus

Identifiers

PMID35126303
PMCPMC8809081
OpenAlexW4206367698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.