Evidence map›Paper›PMID 35126276›Full record

ArticleFrontiers in neurology2021

A J-Shaped Curve Relationship Between Baseline Fasting Blood Glucose and 1-Year Stroke Recurrence in Non-diabetic Patients With Acute Cerebral Infarction in Xi'an, China: A Multicenter Observational Cohort Study.

Zhongzhong Liu, Xuemei Lin, Wenjuan Lin, Qingli Lu, Pei Liu, Jing Wang, Yan Liu, Qiaoqiao Chang, Yan Wang, Chensheng Song and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhongzhong LiuDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Xuemei LinDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Wenjuan LinCollege of Life Science, Northwest University, Xi'an, China.
Qingli LuDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Pei LiuDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Jing WangDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Yan LiuDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Qiaoqiao ChangDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Yan WangDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Chensheng SongDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Fang WangDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Yaling ShiDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Qing WangDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Guozheng LiuDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.
Ye TianDepartment of Neurology, The Affiliated Hospital of Northwest University (Xi'an No.3 Hospital), Xi'an, China.
Songdi WuDepartment of Neurology, The First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital), Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between baseline fasting blood glucose (FBG) levels and 1-year stroke recurrence in non-diabetic patients with acute cerebral infarction (ACI) is unclear. We aimed to clarify this relationship in non-diabetic patients with ACI.

methodsBaseline FBG levels and related information of the patients were collected at admission and the events of stroke recurrence were followed up 1, 3, 6, and 12 months after the patients were discharged. Baseline FBG levels were analyzed as continuous variables and quartiles (Q1-Q4). Multivariate Cox regression models and a two-piecewise linear regression model were used to investigate the relationship and determine the threshold effect between baseline FBG levels and 1-year stroke recurrence in non-diabetic patients with ACI.

resultsOverall, 1,634 non-diabetic patients with ACI were enrolled. After adjusting for potential confounding factors, the hazard is 2.24-fold higher in Q4 than those in Q2, being considered the reference in non-diabetic patients with ACI [hazard ratio (HR) = 2.24, 95%CI: 1.08-4.65,

conclusionLower and higher baseline FBG levels may lead to an increased risk of 1-year stroke recurrence in non-diabetic patients with ACI as shown by a J-shaped curve with a nadir value of 4.6 mmol/L.

Indexed as

acute cerebral infarctionbaseline fasting blood glucosehazardnon-diabeticstroke recurrence

Identifiers

PMID35126276
PMCPMC8810505

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