Evidence map›Paper›PMID 35126169›Full record

ArticleFrontiers in physiology2021

Long Non-coding RNA MALAT1 Is Depleted With Age in Skeletal Muscle

Ling Ruan, Bharati Mendhe, Emily Parker, Andrew Kent, Carlos M Isales, William D Hill, Meghan McGee-Lawrence, Sadanand Fulzele, Mark W Hamrick

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Long non-coding RNAMolecular therapy. Nucleic acids · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Epigenetics of Skeletal Muscle Atrophy.International journal of molecular sciences · 2024
    Review
  16. Noncoding RNA Contribution to Aging and Lifespan.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ling RuanMedical College of Georgia, Augusta University, Augusta, GA, United States.
Bharati MendheMedical College of Georgia, Augusta University, Augusta, GA, United States.
Emily ParkerMedical College of Georgia, Augusta University, Augusta, GA, United States.
Andrew KentMedical College of Georgia, Augusta University, Augusta, GA, United States.
Carlos M IsalesMedical College of Georgia, Augusta University, Augusta, GA, United States.
William D HillDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States.
Meghan McGee-LawrenceMedical College of Georgia, Augusta University, Augusta, GA, United States.
Sadanand FulzeleMedical College of Georgia, Augusta University, Augusta, GA, United States.
Mark W HamrickMedical College of Georgia, Augusta University, Augusta, GA, United States.
Augusta University · USMedical University of South Carolina · US

Funding

Kynurenine Pathway Regulation of CNS Senescence in Alzheimer's Disease PathologyR01AG067510 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HILL, WILLIAM D, MCGEE-LAWRENCE, MEGHAN E. · 2020 to 2023
$2.4M
CSRD VA I01 CX000930NIA NIH HHS R01 AG067510
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are thought to function as "sponges" for microRNAs, but a role for such competing endogenous RNAs (ceRNAs) in muscle aging is not well understood. We therefore examined in skeletal muscles of young (4-6 months) and aged (22-24) male and female mice the expression of lncRNA MALAT1, which is predicted

Indexed as

fibrosisoxidative stresssarcopeniasenescencesiRNA

Identifiers

PMID35126169
PMCPMC8814451
OpenAlexW4206897559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.