Evidence map›Paper›PMID 35126135›Full record

ArticleFrontiers in pharmacology2021

Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model.

Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Joseph McCollum, Leah Mellett, Rosemary Swanson, Ananya Gupta, Nicholas B Carrigy, Hui Wang, David Barona and 11 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mellissa GomezDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Mushtaq AhmedDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States.
Shibali DasDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States.
Joseph McCollumInfectious Disease Research Institute, Seattle, WA, United States.
Leah MellettDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States.
Rosemary SwansonDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States.
Ananya GuptaDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States.
Nicholas B CarrigyDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Hui WangDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
David BaronaDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Shital BachchhavDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Alana GerhardtInfectious Disease Research Institute, Seattle, WA, United States.
Chris PressInfectious Disease Research Institute, Seattle, WA, United States.
Michelle C ArcherInfectious Disease Research Institute, Seattle, WA, United States.
Hong LiangInfectious Disease Research Institute, Seattle, WA, United States.
Emilie SeydouxInfectious Disease Research Institute, Seattle, WA, United States.
Ryan M KramerInfectious Disease Research Institute, Seattle, WA, United States.
Philip J KuehlLovelace Biomedical, Albuquerque, NM, United States.
Reinhard VehringDepartment of Mechanical Engineering, University of Alberta, Edmonton, AB, Canada.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St. Louis, MO, United States.
Christopher B FoxInfectious Disease Research Institute, Seattle, WA, United States.

Funding

PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1M
NHLBI NIH HHS T32 HL007317
6 · The paper itself

Abstract

Converting a vaccine into a thermostable dry powder is advantageous as it reduces the resource burden linked with the cold chain and provides flexibility in dosage and administration through different routes. Such a dry powder presentation may be especially useful in the development of a vaccine towards the respiratory infectious disease tuberculosis (TB). This study assesses the immunogenicity and protective efficacy of spray-dried ID93+GLA-SE, a promising TB vaccine candidate, against

Indexed as

dry powder vaccineID93+GLA-SEin vivo murine modelnose-only inhalation deviceparticle engineeringrespiratory deliverytuberculosisvaccine adjuvant formulation

Identifiers

PMID35126135
PMCPMC8814656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.