ArticleFrontiers in neuroscience2021
Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy.Journal of neural engineering · 2026Article
- Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment.Neuroimage. Reports · 2026Article
- Commonalities and distinctions of static and dynamic functional connectivity density between left and right temporal lobe epilepsy.Scientific reports · 2026Article
- Static and dynamic intracerebral signal analysis reveals protective networks against seizures in drug-resistant focal epilepsy.Brain communications · 2026Article
- Cross-sectional and longitudinal changes in category selectivity in visual cortex following pediatric cortical resection.Communications biology · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls.CNS neuroscience & therapeutics · 2025Article
- Computational modelling reveals neurobiological contributions to static and dynamic functional connectivity patterns.Frontiers in computational neuroscience · 2025Article
- Dynamic functional connectivity and gene expression correlates in temporal lobe epilepsy: insights from hidden markov models.Journal of translational medicine · 2024Article
- Similarities and differences of dynamic and static spontaneous brain activity between left and right temporal lobe epilepsy.Brain imaging and behavior · 2024Article
- Temporal and topological properties of dynamic networks reflect disability in patients with neuromyelitis optica spectrum disorders.Scientific reports · 2024Article
- Syncing the brain's networks: dynamic functional connectivity shifts from temporal interference.Frontiers in human neuroscience · 2024Article
- Article
- Reorganization of Dynamic Network in Stroke Patients and Its Potential for Predicting Motor Recovery.Neural plasticity · 2024Article
- Abnormal brain functional network dynamics in sleep-related hypermotor epilepsy.CNS neuroscience & therapeutics · 2023Article
- Effect of intracranial electrical stimulation on dynamic functional connectivity in medically refractory epilepsy.Frontiers in human neuroscience · 2023Article
- Alterations in static and dynamic regional homogeneity in mesial temporal lobe epilepsy with and without initial precipitating injury.Frontiers in neuroscience · 2023Article
- Large-scale dysfunctional white matter and grey matter networks in patients with social anxiety disorder.iScience · 2022Article
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Authors and funding
10 authors.
Funding
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Abstract
objectiveTemporal lobe epilepsy (TLE) can be conceptualized as a network disease. However, the network characteristics in lateralization remain controversial.
methodsIn this study, resting-state functional MRI scans were acquired from 53 TLE patients [22 with left-side TLE (LTLE) and 31 with right-side TLE (RTLE)] and 37 matched healthy controls. We focused on the characteristics of static and dynamic functional connectivity, including static connectivity patterns and topological properties, as well as temporal properties of the dynamic connectivity state and the variability of the dynamic connectivity and network topological organization. Correlation analyses were conducted between abnormal static and dynamic properties and cognitive performances.
resultsThe static functional connectivity analysis presented a significantly decreased cortical-cortical connectivity pattern and increased subcortical-cortical connectivity pattern in RTLE. The global-level network in RTLE showed a significant decrease in global efficiency. The dynamic functional connectivity analysis revealed that RTLE patients exhibited aberrant connectivity states, as well as increased variability in the subcortical-cortical connectivity. The global-level network in RTLE revealed increased variance in global efficiency and local efficiency. The static or dynamic functional connectivity in LTLE did not show any significant abnormalities. The altered dynamic properties were associated with worsening cognitive performance in language and conceptual thinking by the TLE patients.
conclusionOur findings demonstrated the presence of abnormalities in the static and dynamic functional connectivity of TLE patients. RTLE patients exhibited more pronounced aberrant connectivity patterns and topological properties, which might represent a mechanism for reconfiguration of brain networks in RTLE patients. These observations extended our understanding of the pathophysiological network mechanisms of TLE.
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