Evidence map›Paper›PMID 35126041›Full record

ArticleFrontiers in neuroscience2021

Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death.

Ian C Wenker, Elizabeth A Blizzard, Pravin K Wagley, Manoj K Patel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ian C WenkerDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, United States.
Elizabeth A BlizzardDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, United States.
Pravin K WagleyDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, United States.
Manoj K PatelDepartment of Anesthesiology, University of Virginia, Charlottesville, VA, United States.
University of Virginia · US

Funding

Role of brainstem cardiorespiratory neurons in SUDEPR01NS122834 · NINDS · UNIVERSITY OF VIRGINIA · PI MANOJ K PATEL · 2022 to 2026
$2.1M
Role of CACHD1 in the development of temporal lobe epilepsy and absence epilepsyR01NS120702 · NINDS · UNIVERSITY OF VIRGINIA · PI PATEL, MANOJ K · 2021 to 2025
$2.0M
Pathogenesis of epilepsy in a SCN8A human mutation mouse modelR01NS103090 · NINDS · UNIVERSITY OF VIRGINIA · PI PATEL, MANOJ K · 2018 to 2022
$1.8M
NINDS NIH HHS R01 NS103090NINDS NIH HHS R01 NS120702NINDS NIH HHS R01 NS122834
6 · The paper itself

Abstract

Sudden unexpected death in epilepsy (SUDEP) accounts for the deaths of 8-17% of patients with epilepsy. Although the mechanisms of SUDEP are unknown, one proposed mechanism is abnormal control of the heart by the autonomic nervous system (ANS). Our objective was to determine whether the broad changes in ictal heart rate experienced by mouse models of SUDEP are (1) due to the ANS and (2) contribute to seizure-induced death. Seizures were induced by electrical stimulation of the hippocampus of a mouse carrying the human

Indexed as

apneabradycardiaepilepsySCN8A encephalopathyseizureSUDEP (sudden unexplained death in epilepsy)tonic phase

Identifiers

PMID35126041
PMCPMC8813980
OpenAlexW4205697774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.