ArticlePostepy dermatologii i alergologii2021
Evaluation of cutaneous side-effects associated with chemotherapeutic use in oncological patients.
Article in Postepy dermatologii i alergologii, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Ginsenoside Rh2 Induces HeLa Apoptosis through Upregulating Endoplasmic Reticulum Stress-Related and Downstream Apoptotic Gene Expression.Molecules (Basel, Switzerland) · 2022Article
- Olaparib-induced cutaneous side effects in a patient with recurrent ovarian cancer.BMJ case reports · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSide-effects are frequently encountered in classic chemotherapy. However, the recent development of targeted treatments has resulted in a diminution of these. The most common side-effects are dermatological.
aimTo investigate cutaneous changes occurring in patients using classic and targeted chemotherapeutic agents, and the prevalence of these changes in the two groups. MATERIAL AND
methodsOne hundred twenty-eight volunteer oncological patients using chemotherapeutic agents were included in this prospective study. Two subgroups were established, patients using classic and those using targeted chemotherapeutic agents.
resultsXerosis was the most common side-effect, being seen in 93 (72.7%) of the 128 patients. Other common side-effects included alopecia, pruritus, mucositis, skin pigmentation, and palmar-plantar erythema. The most common side-effects in the classic chemotherapeutic group were xerosis seen in 71 (75.5%) patients, pruritus in 50 (53.2%), alopecia in 49 (52.1%), and nail changes in 43 (45.7%). The most common side-effects in the targeted chemotherapeutic group were xerosis seen in 22 (64.7%) patients, nail changes in 17 (50%), alopecia in 15 (44.1%), and pruritus in 13 (38.2%).
conclusionsThe most common cutaneous side-effects were less prevalent in the patient group using targeted chemotherapeutic agents than in the classic group. Various side-effects associated with chemotherapeutic use which had not been previously reported were also identified in this study. Classic chemotherapeutic agents caused more serious side-effects requiring discontinuation of treatment than targeted chemotherapeutic agents.
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