Evidence map›Paper›PMID 35126007›Full record

ArticlePostepy dermatologii i alergologii2021

Is the composition of exhaled breath condensate a key to explain the course of COVID-19 in children?

Alicja Krejner-Bienias, Katarzyna Grzela, Rafal Krenke, Katarzyna Gorska, Patrycja Nejman-Gryz, Dorota Stadnik, Ewa Kobylska, Tomasz Grzela

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Postepy dermatologii i alergologii, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alicja Krejner-BieniasDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Katarzyna GrzelaDepartment of Paediatric Pulmonology and Allergy, Medical University of Warsaw, Warsaw, Poland.
Rafal KrenkeDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.
Katarzyna GorskaDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.
Patrycja Nejman-GryzDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.
Dorota StadnikLukasiewicz Research Network - Institute of Biotechnology and Antibiotics, Warsaw, Poland.
Ewa KobylskaLukasiewicz Research Network - Institute of Biotechnology and Antibiotics, Warsaw, Poland.
Tomasz GrzelaDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PLInstytut Biotechnologii i Antybiotyków · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe relative resistance of children to severe course of the novel coronavirus infection remains unclear. We hypothesized that there might be a link between this phenomenon and observation from our previous studies concerning an inhibitory or cytotoxic effect of exhaled breath condensate (EBC) on endothelial cell cultures in children.

aimSince we could not find any data on the similar effect caused by EBC in adults, the aim of our study was to evaluate and compare the biological activity of EBC in adults and children in an experimental MATERIAL AND

methodsThe influence of EBC samples on metabolic activity of endothelial cell line C-166 was assessed using colorimetric tetrazolium salt reduction assay (MTT assay). Selected EBC samples were fractionated using size exclusion chromatography and subjected to mass spectrometry analysis.

resultsExhaled breath condensates in healthy children, but not in adults, revealed a cytotoxic effect on

conclusionsBreath condensates of healthy children contain the factor which reveals the inhibitory/cytotoxic effect on endothelial cell cultures. Although the physiological role of this agent remains unclear, its identification may potentially be useful in ongoing research on SARS-CoV-2/COVID-19.

Indexed as

exhaled breath condensateKawasaki-like syndromeSARS-CoV-2/COVID-19

Identifiers

PMID35126007
PMCPMC8802949
OpenAlexW3108347300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.