Evidence map›Paper›PMID 35125963›Full record

ArticleMediators of inflammation2022

Phosphorylation at Ser 727 Increases STAT3 Interaction with PKC

Xiongjuan Li, Biqiang Zhou, Han Yang, Xinping Yang, Zhao Zhao, Zhenglong Pan, Xinran Liao, Wenling Jian, Yuqiang Liu, Han Lu and 6 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Xiongjuan LiDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.ORCID https://orcid.org/0000-0003-4494-9579
Biqiang ZhouDepartment of Geriatric & Spinal Pain Multi-Department Treatment, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Han YangDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Xinping YangDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Zhao ZhaoDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Zhenglong PanDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Xinran LiaoDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Wenling JianDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Yuqiang LiuDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.
Han LuDepartment of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025, China.
Qingsheng XueDepartment of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025, China.
Yan LuoDepartment of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025, China.
Buwei YuDepartment of Anesthesiology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025, China.
Huansen HuangDepartment of Anesthesiology, Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgangxi Road, Guangzhou 510260, China.
Daqing MaDivision of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.ORCID https://orcid.org/0000-0002-0688-2097
Zhiheng LiuDepartment of Anesthesiology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen 518035, China.ORCID https://orcid.org/0000-0002-2823-543X
Shenzhen University Health Science Center · CNRuijin Hospital · CNChelsea and Westminster Hospital · GBSecond Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsA rat hyperalgesia model was induced using an intraplantar injection of Freund's complete adjuvant (FCA) or an intrathecal injection of IL-6. Mechanical allodynia was evaluated using von Frey filament tests after intrathecal injections of T-5224 (c-Fos/AP-1 inhibitor), minocycline (Mino, a specific microglia inhibitor), L-2-aminoadipic acid (LAA, an astroglial toxin), PKC

resultsT-5224, Mino, and LAA attenuated FCA- or IL-6-mediated inflammatory pain, with a decrease in c-Fos, GFAP, Iba-1, PKC

conclusionSTAT3 phosphorylation at Ser 727 and the interaction with PKC

Indexed as

HyperalgesiaInterleukin-6AnimalsNeurogliaNeuronsPhosphorylationProtein Kinase C-epsilonRatsSpinal CordInterleukin-6Protein Kinase C-epsilon

Identifiers

PMID35125963
PMCPMC8816592
OpenAlexW4210727001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.