ArticleInternational journal of nanomedicine2022
The Application of Pulp Tissue Derived-Exosomes in Pulp Regeneration: A Novel Cell-Homing Approach.
Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Efficacy of dental stem cell-derived exosomes for pulp regeneration: a systematic review of clinical, animal, and in vitro studies.Molecular biology reports · 2026Pooled it
- Extracellular vesicle therapies in regenerative endodontic procedures: A systematic review and meta-analysis of in vivo studies.Science progressPooled it
- Extracellular Matrix-Based and Extracellular Matrix-Bioinspired Scaffolds for Extracellular Vesicle Delivery in Dental Pulp Regeneration: A Narrative Review.Biotech (Basel (Switzerland)) · 2026Review
- Review
- Pulp-Dentin Regeneration via Cell Homing: Current Evidence and Perspectives on Cell-Free Regenerative Endodontic Therapy.Medicina (Kaunas, Lithuania) · 2026Review
- Tissue regeneration strategies based on mesenchymal stem cell-derived extracellular vesicles: from bench to bedside.Burns & trauma · 2026Review
- Mechanistic insights into dental stem cells-derived exosomes in regenerative endodontics.International endodontic journal · 2025Review
- Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025Review
- Regenerative endodontic therapy: From laboratory bench to clinical practice.Journal of advanced research · 2025Review
- Engineering organoids for dental pulp tissue regeneration and functional reconstruction.Regenerative medicine · 2025Review
- Age-Related Oral and Para-Oral Tissue Disorders: The Evolving Therapeutic and Diagnostic Potential of Exosomes.Dentistry journal · 2025Review
- Emerging roles of extracellular vesicles in oral and maxillofacial areas.International journal of oral science · 2025Review
- Protocol for the isolation and characterization of porcine brain region-associated extracellular particles.PloS one · 2025Article
- Regenerative endodontic therapy in immature teeth using photobiomodulation and photodynamic therapy; a histomorphological study in canine model.BMC oral health · 2024Article
- Extracellular vesicles as therapeutic tools in regenerative dentistry.Stem cell research & therapy · 2024Review
- Tissue engineering approaches for dental pulp regeneration: The development of novel bioactive materials using pharmacological epigenetic inhibitors.Bioactive materials · 2024Review
- Developing functional hydrogels for treatment of oral diseases.Smart medicine · 2024Review
- Dental pulp regeneration strategies: A review of status quo and recent advances.Bioactive materials · 2024Review
- Enhancing Vasculogenesis in Dental Pulp Development: DPSCs-ECs Communication via FN1-ITGA5 Signaling.Stem cell reviews and reports · 2024Article
- Advances in Regenerative Dentistry Approaches: An Update.International dental journal · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExosomes derived from stem cells, as an alternative to stem cells themselves, have been employed for dental pulp regeneration. However, it is not known whether exosomes can recruit host cells to the regeneration process. In this study, we built a "cell homing" model to determine whether exosomes derived from dental pulp tissue (DPT-exos) can regenerate dental pulp by recruiting the stem cells from the apical dental papilla (SCAPs).
methodsExosomes were isolated from the dental pulp tissue (DPT-exos) and dental pulp stem cells (DPC-exos) of swine. The effects of the exosomes on SCAPs were compared using CKK-8, Transwell, angiogenesis, and odontogenic induction assays. DPT-exos and DPC-exos were investigated in an in vivo "cell homing" model using swine teeth to compare their roles in pulp regeneration. To build the model, we placed SCAP-containing collagen gel at the root tip and filled the cavity of the treated dental matrix (TDM) with DPT-exos and DPC-exos-laden scaffolds, which would be expected to recruit SCAPs to the pulp cavity. The complex was then implanted subcutaneously into immunodeficient nude mice. After eight weeks, tissue samples were taken and analyzed histologically to determine whether the DPT-exos contributed to pulp regeneration through "cell homing".
resultsExosomes were successfully extracted from dental pulp tissue and confirmed to be exosomes. In vitro tests confirmed that DPT-exos performed better than DPC-exos in promoting the migration, proliferation, and differentiation of SCAPs. Furthermore, DPT-exos recruited SCAPs to regenerate dental pulp-like connective tissue in vivo containing collagen, odontoblasts, and enriched predentin-like tissue. Blood vessel growth was demonstrated by immunofluorescence.
conclusionThis study demonstrated the ability of DPT-exos to induce SCAPs to regenerate connective tissue similar to natural dental pulp. This technique has the potential for treating pulp deficiency caused by various pulp diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.