Evidence map›Paper›PMID 35125142›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2022

Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus.

Roberto Martin Del Campo-Vera, Austin M Tang, Angad S Gogia, Kuang-Hsuan Chen, Rinu Sebastian, Zachary D Gilbert, George Nune, Charles Y Liu, Spencer Kellis, Brian Lee

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In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberto Martin Del Campo-VeraDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Austin M TangDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. Electronic address: austint@usc.edu.
Angad S GogiaDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Kuang-Hsuan ChenDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Rinu SebastianDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Zachary D GilbertDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
George NuneDepartment of Neurology, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA.
Charles Y LiuDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Spencer KellisDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA; Tianqiao and Chrissy Chen Brain-Machine Interface Center, Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA, USA.
Brian LeeDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA; USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.

Funding

Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
NCATS NIH HHS KL2 TR001854
6 · The paper itself

Abstract

introductionThe hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13-30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to study human hippocampal beta-power changes during movement. MATERIALS AND

methodsTen epilepsy patients (5 female; ages 21-46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta-band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior vs posterior contacts, ipsilateral vs contralateral contacts, and male vs female beta-power values.

resultsEight out of ten patients showed significant beta-power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta-power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral vs contralateral contacts nor in anterior vs posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001).

conclusionThese findings indicate that increases in hippocampal beta power are associated with movement inhibition. To the best of our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.

Indexed as

ElectroencephalographyEpilepsyAdultFemaleHippocampusHumansMaleMiddle AgedMovementYoung AdultBeta bandhippocampushumanmodulationmotor inhibitionpower spectrumstereo EEG

Identifiers

PMID35125142
PMCPMC8727636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.