ArticleBrain injury2022
Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans.
Article in Brain injury, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Identifying risk factors of young-onset dementia and evaluating evidence hierarchy: a meta-analysis and umbrella review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Environmental and lifestyle risk factors for early-onset dementia: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Reducing burden and anxiety for caregivers of veterans with traumatic brain injury and dementia: Randomized controlled trial of the resources for enhancing all caregivers' health-Hope intervention.Rehabilitation psychology · 2026Trial
- Comorbidities and health-care use prior to early-onset Alzheimer's disease: A population-based case-control study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Home- and Community-Based Service Use and Preferences Among Post-9/11 Veterans With or at High Risk of Alzheimer Disease and Related Dementia and Their Caregivers: Protocol for a Mixed Methods Observational Study.JMIR research protocols · 2026Observational
- History of Traumatic Brain Injury with Loss of Consciousness and APOEbioRxiv : the preprint server for biology · 2026Article
- Sex Differences in Cardiovascular Disease Outcomes After Traumatic Brain Injury.JACC. Advances · 2026Article
- Traumatic brain injury and risk of early-onset dementia: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Racial/Ethnic and Geographic Differences in Traumatic Brain Injury (TBI) Service-Connected Disability Determination and Monthly Compensation Among Post-9/11 US Veterans.Journal of racial and ethnic health disparities · 2026Article
- Mediators of epilepsy risk after traumatic brain injury: A 20-year U.S. veteran cohort study.Epilepsia · 2025Article
- Article
- Immune Response in Traumatic Brain Injury.Current neurology and neuroscience reports · 2024Review
- Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures.Scientific reports · 2024Article
- Demographics, Clinical Characteristics, and Well-Being of Veterans with TBI and Dementia and Their Caregivers.Geriatrics (Basel, Switzerland) · 2024Article
- Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.Brain sciences · 2024Article
- Demographic characteristics and epigenetic biological aging among post-9/11 veterans: Associations of DunedinPACE with sex, race, and age.Psychiatry research · 2024Article
- Preparing Veterans Health Administration Psychologists to Meet the Complex Needs of Aging Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Article
- Traumatic Brain Injury and Subsequent Risk of Brain Cancer in US Veterans of the Iraq and Afghanistan Wars.JAMA network open · 2024Article
- Identifying clinical phenotypes of frontotemporal dementia in post-9/11 era veterans using natural language processing.Frontiers in neurology · 2024Article
- The role of nutrition in mild traumatic brain injury rehabilitation for service members and veterans.NeuroRehabilitation · 2024Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo assess traumatic brain injury (TBI)-related risks factors for early-onset dementia (EOD).
backgroundYounger Post-9/11 Veterans may be at elevated risk for EOD due to high rates of TBI in early/mid adulthood. Few studies have explored the longitudinal relationship between traumatic brain injury (TBI) and the emergence of EOD subtypes.
methodsThis matched case-control study used data from the Veterans Health Administration (VHA) to identify Veterans with EOD. To address the low positive predictive value (PPV = 0.27) of dementia algorithms in VHA records, primary outcomes were Alzheimer's disease (AD) and frontotemporal dementia (FTD). Logistic regression identified conditions associated with dementia subtypes.
resultsThe EOD cohort included Veterans with AD (n = 689) and FTD (n = 284). There were no significant demographic differences between the EOD cohort and their matched controls. After adjustment, EOD was significantly associated with history of TBI (OR: 3.05, 2.42-3.83), epilepsy (OR: 4.8, 3.3-6.97), other neurological conditions (OR: 2.0, 1.35-2.97), depression (OR: 1.35, 1.12-1.63) and cardiac disease (OR: 1.36, 1.1-1.67).
conclusionPost-9/11 Veterans have higher odds of EOD following TBI. A sensitivity analysis across TBI severity confirmed this trend, indicating that the odds for both AD and FTD increased after more severe TBIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.