ArticleBrain injury2022
Advanced brain age in deployment-related traumatic brain injury: A LIMBIC-CENC neuroimaging study.
Article in Brain injury, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Accelerated Aging after Traumatic Brain Injury: An ENIGMA Multi-Cohort Mega-Analysis.Annals of neurology · 2024Pooled it
- Article
- Article
- Structural Magnetic Resonance Imaging Brain Age Investigation in Athletes with Persistent Postconcussion Syndrome.Neurotrauma reports · 2025Article
- Predicting brain age for veterans with traumatic brain injuries and healthy controls: an exploratory analysis.Frontiers in aging neuroscience · 2025Article
- Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury.Brain communications · 2025Review
- Article
- Mechanisms Underlying Hazardous Alcohol Use After Mild Traumatic Brain Injury.Alcohol research : current reviews · 2025Review
- The Effects of Early Life History of TBI on the Progression of Normal Brain Aging with Implications for Increased Dementia Risk.Advances in neurobiology · 2024Review
- Sex-difference in the association between social drinking, structural brain aging and cognitive function in older individuals free of cognitive impairment.Frontiers in psychiatry · 2024Article
- Increased brain age and relationships with blood-based biomarkers following concussion in younger populations.Journal of neurology · 2023Article
- Military-related mild traumatic brain injury: clinical characteristics, advanced neuroimaging, and molecular mechanisms.Translational psychiatry · 2023Review
- Significant Acceleration of Regional Brain Aging and Atrophy After Mild Traumatic Brain Injury.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Traumatic brain injury: progress and challenges in prevention, clinical care, and research.The Lancet. Neurology · 2022Review
- Traumatic Brain Injury and Accelerated Epigenetic Aging Among Post-9/11 Veterans.The Journal of head trauma rehabilitationArticle
Corrections and comments
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Authors and funding
25 authors at 14 institutions in 2 countries.
Funding
Abstract
objectiveTo determine if history of mild traumatic brain injury (mTBI) is associated with advanced or accelerated brain aging among the United States (US) military Service Members and Veterans.
methodsEight hundred and twenty-two participants (mean age = 40.4 years, 714 male/108 female) underwent MRI sessions at eight sites across the US. Two hundred and one participants completed a follow-up scan between five months and four years later. Predicted brain ages were calculated using T1-weighted MRIs and then compared with chronological ages to generate an Age Deviation Score for cross-sectional analyses and an Interval Deviation Score for longitudinal analyses. Participants also completed a neuropsychological battery, including measures of both cognitive functioning and psychological health.
resultIn cross-sectional analyses, males with a history of deployment-related mTBI showed advanced brain age compared to those without (
conclusionHistory of deployment-related mTBI, severity of PTSD and depression symptoms, and alcohol misuse are associated with advanced brain aging in male US military Service Members and Veterans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.