Evidence map›Paper›PMID 35125035›Full record

ArticleEuropean journal of ophthalmology2022

Analysis of tear film in cystinosis patients treated with topical viscous cysteamine hydrochloride (Cystadrops

Petroni Sergio, Iarossi Giancarlo, Federici Matteo, De Sanctis Carlo Maria, Petrocelli Gianni, Rosa Parrilla, Paola Valente, Buzzonetti Luca

Open access · hybridAbstract read
In one paragraph

Article in European journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Petroni SergioOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID 0000-0003-0449-969X
Iarossi GiancarloOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Federici MatteoOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
De Sanctis Carlo MariaOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Petrocelli GianniOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Rosa ParrillaOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Paola ValenteOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Buzzonetti LucaOphthalmology Department, 9342Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID 0000-0002-3200-3260
Bambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate

methodsTen eyes of five patients with nephropathic cystinosis aged from 10 to 35 years were included in this study. The patients were under treatment with viscous cysteamine hydrochloride formulation containing 3.8 mg/mL cysteamine (vCH 0.55%, equivalent to 0.55% CH; Cystadrops

resultsMean tear osmolarity was 294.8 mOsms/L (±10.4), with a mean absolute difference of 1.85 mOsms/L (±2.13) between the eyes. There was no statistically significant difference between the osmolarity readings of cystinosis and the control group (294.8 ± 10.4 vs 299.4 ± 6.2mOsm/L, respectively; p = 0.39). The mean TBUT was 10.2 ± 0.83 s in the study group versus 10 ± 0.7 s in controls (p = 0.62). The mean Schirmer test score was 9.2 ± 0.83 mm in the patients versus 10.2 ± 0.83 mm in the controls (p = 0.14).

conclusionsThe TearLab

Indexed as

CystinosisDry Eye SyndromesCorneaCysteamineHumansOsmolar ConcentrationReproducibility of ResultsTearsCysteaminecorneal crystalocular cystinosistear osmolarity

Identifiers

PMID35125035
PMCPMC9527349
OpenAlexW4210944439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.