ArticleIntestinal research2022
Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease.
Article in Intestinal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Infections in primary sclerosing cholangitis and inflammatory bowel disease: a systematic review and meta-analysis.Journal of the Canadian Association of Gastroenterology · 2025Article
- Prevalence and risk factors of gallstone disease in Korean patients with ulcerative colitis.Intestinal research · 2025Article
- Safety of Biologics and Small Molecules for Inflammatory Bowel Diseases in Organ Transplant Recipients.Yonsei medical journal · 2024Article
- Hepatic Steatosis but Not Fibrosis Is Independently Associated with Poor Outcomes in Patients with Inflammatory Bowel Disease.Gut and liver · 2024Article
- Treatment of primary sclerosing cholangitis combined with inflammatory bowel disease.Intestinal research · 2023Review
- Regional variations in the prevalence of primary sclerosing cholangitis associated with inflammatory bowel disease.Intestinal research · 2023Article
- Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut-liver axis.Experimental & molecular medicine · 2023Review
- Incidence and adverse clinical events of primary sclerosing cholangitis with ulcerative colitis.International journal of colorectal disease · 2023Article
- The Impact of Concomitant Ulcerative Colitis on the Clinical Course in Patients with Primary Sclerosing Cholangitis: An Investigation Using a Nationwide Database in Japan.Inflammatory intestinal diseases · 2023Article
- Is primary sclerosing cholangitis with inflammatory bowel disease different between patients in the East and West?Intestinal research · 2022Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsPrimary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD.
methodsThis retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively.
resultsIn total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679).
conclusionsA 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.
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