Evidence map›Paper›PMID 35124779›Full record

ReviewCurrent pain and headache reports2022

Modulatory Effects of Stem Cells on Opioid Receptors and Neuroinflammation.

Matthew Meroney, Joshua Winegar, Holden Brown, Mark Bender, Scott Smith, Rene Przkora

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthew MeroneyDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA. mmeroney@anest.ufl.edu.ORCID http://orcid.org/0000-0001-9884-0347
Joshua WinegarDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Holden BrownDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Mark BenderDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Scott SmithDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
Rene PrzkoraDepartment of Anesthesiology, University of Florida College of Medicine, Gainesville, FL, 32610, USA.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis narrative review examines stem cell therapy and its effect on opioid therapy in neuropathic pain. RECENT

findingsStem cell therapy has shown promise in neuropathic pain and opioid tolerance, with a notable common pathway (the P2X4 receptor). Opioid therapy frequently has poor efficacy in patients who suffer from neuropathic pain. There is evidence that the presence of neuropathic pain itself causes changes to the opioid receptor, decreasing the therapeutic potential of this modality. The efficacy of opioid therapy is further decreased in this patient population after chronic opioid exposure, which leads to opioid tolerance and in some cases opioid-induced hyperalgesia. There is growing evidence that stem cell therapy has potential to treat neuropathic pain and may simultaneously decrease opioid tolerance and hyperalgesia. Opioid-induced hyperalgesia occurs via mu-opioid receptor-dependent expression of P2X4 receptors on microglia. Intrathecal stem cell therapy provides analgesic properties due to the significant reduction of P2X4R expression in spinal cord microglia, thereby directly decreasing chronic neuropathic pain.

Indexed as

Analgesics, OpioidReceptors, OpioidDrug ToleranceHumansHyperalgesiaNeuroinflammatory DiseasesSpinal CordStem CellsAnalgesics, OpioidReceptors, OpioidDrug toleranceHyperalgesiaNeuralgiaOpioid analgesicsOpioid receptorsPain management

Identifiers

PMID35124779
OpenAlexW4210820478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.