ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2022
Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies.
Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- From rosemary and coffee to bioactive nanovesicles: exploring new frontiers in food functional ingredients.NPJ science of food · 2026Article
- Bioassembly of Myoblast Spheroids in Electrofibrillated Scaffolds for 3D Muscle Tissue Biofabrication.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Ameliorative effects ofMolecular medicine reports · 2025Article
- Impact of Extremely Low-Frequency Electromagnetic Fields on Skeletal Muscle of Sedentary Adult Mice: A Pilot Study.International journal of molecular sciences · 2024Article
- Edible mycelium as proliferation and differentiation support for anchorage-dependent animal cells in cultivated meat production.NPJ science of food · 2024Article
- Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress.International journal of molecular sciences · 2023Article
Corrections and comments
- Retracted
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA low-frequency electromagnetic field (LF-EMF) exerts important biological effects on the human body.
objectiveWe previously studied the immunity and atrophy of gastrocnemius muscles in rats with spinal cord injuries and found that LF-EMF with a magnetic flux density of 1.5 mT exerted excellent therapeutic and preventive effects on reducing myotubes and increasing spatium intermusculare. However, the effects of LF-EMF on all stages of skeletal myogenesis, such as activation, proliferation, differentiation, and fusion of satellite cells to myotubes as stimulated by myogenic regulatoryfactors (MRFs), have not been fully elucidated.
methodsThis study investigated the optimal LF-EMF magnetic flux density that exerted maximal effects on all stages of C2C12 cell skeletal myogenesis as well as its impact on regulatory MRFs.
resultsThe results showed that an LF-EMF with a magnetic flux density of 2.0 mT could activate C2C12 cells and upregulate the proliferation-promoting transcription factor PAX7. On the other hand, 1.5 mT EMF could upregulate the expression of MyoD and myogenin.
conclusionLF-EMF could prevent the disappearance of myotubes, with different magnetic flux densities of LF-EMF exerting independent and positive effects on skeletal myogenesis such as satellite cell activation and proliferation, muscle cell differentiation, and myocyte fusion.
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