Evidence map›Paper›PMID 35124204›Full record

ArticleNitric oxide : biology and chemistry2022

Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxides.

Swati Basu, Karina Ricart, Mark T Gladwin, Rakesh P Patel, Daniel B Kim-Shapiro

Open access · greenAbstract read
In one paragraph

Article in Nitric oxide : biology and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Swati BasuTranslational Science Center and Department of Physics, Wake Forest University, USA.
Karina RicartDepartment of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, USA.
Mark T GladwinUniversity of Pittsburgh School of Medicine, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine and Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, Pittsburgh, PA, USA.
Rakesh P PatelDepartment of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, USA. Electronic address: rakeshpatel@uabmc.edu.
Daniel B Kim-ShapiroTranslational Science Center and Department of Physics, Wake Forest University, USA. Electronic address: shapiro@wfu.edu.
University of Alabama at Birmingham · USWake Forest University · USUniversity of Pittsburgh · US

Funding

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5M
Oral nitrate metabolism as a predictor for bronchopulmonary in preterm infantsR21HD100917 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GENTLE, SAMUEL J, PATEL, RAKESH P. · 2020 to 2021
$408k
NHLBI NIH HHS R01 HL098032NICHD NIH HHS R21 HD100917
6 · The paper itself

Abstract

Nitric Oxide (NO) is an important signaling molecule that plays roles in controlling vascular tone, hemostasis, host defense, and many other physiological functions. Low NO bioavailability contributes to pathology and NO administration has therapeutic potential in a variety of diseases. Thus, accurate measurements of NO bioavailability and reactivity are critical. Due to its short lifetime in vivo and many in vitro conditions, NO bioavailability and reactivity are often best determined by measuring NO congeners and metabolites that are more stable. Chemiluminescence-based detection of NO following chemical reduction of these compounds using the tri-iodide and vanadium chloride methods have been widely used in a variety of clinical and laboratory studies. In this review, we describe these methods used to detect nitrite, nitrate, nitrosothiols and other species and discuss limitations and proper controls.

Indexed as

Luminescent MeasurementsChloridesHumansIodidesNitrogen OxidesVanadiumChloridesIodidesNitrogen OxidesVanadiumChemiluminescence detectionNitrateNitric oxideNitriteNitrosothiols

Identifiers

PMID35124204
PMCPMC8860884
OpenAlexW4210727802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.