Evidence map›Paper›PMID 35124155›Full record

ReviewNeuroscience and biobehavioral reviews2022

Translational relevance of forward genetic screens in animal models for the study of psychiatric disease.

Eva Sheardown, Aleksandra M Mech, Maria Elena Miletto Petrazzini, Adele Leggieri, Agnieszka Gidziela, Saeedeh Hosseinian, Ian M Sealy, Jose V Torres-Perez, Elisabeth M Busch-Nentwich, Margherita Malanchini and 1 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Eva SheardownSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Aleksandra M MechSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Maria Elena Miletto PetrazziniDepartment of Biomedical Sciences, University of Padova, Via Ugo Bassi, 58/B, 35131 Padova, Italy.
Adele LeggieriSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Agnieszka GidzielaSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Saeedeh HosseinianSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Ian M SealyCambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
Jose V Torres-PerezUK Dementia Research Institute at Imperial College London and Department of Brain Sciences, Imperial College London, 86 Wood Lane, London W12 0BZ, UK.
Elisabeth M Busch-NentwichSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Margherita MalanchiniSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK.
Caroline H BrennanSchool of Biological and Behavioural Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, England, UK. Electronic address: c.h.brennan@qmul.ac.uk.
Queen Mary University of London · GBUK Dementia Research Institute · GBUniversity of Cambridge · GBUniversity of Padua · IT

Funding

Exploiting zebrafish genetics to identify genes affecting addiction-related phenotypes.U01DA044400 · NIDA · UNIV/LONDON-QUEEN MARY& WESTFIELD COLL · PI BRENNAN, CAROLINE HELEN, BUSCH-NENTWICH, ELISABETH MARIE · 2018 to 2022
$2.0M
NIDA NIH HHS U01 DA044400
6 · The paper itself

Abstract

Psychiatric disorders represent a significant burden in our societies. Despite the convincing evidence pointing at gene and gene-environment interaction contributions, the role of genetics in the etiology of psychiatric disease is still poorly understood. Forward genetic screens in animal models have helped elucidate causal links. Here we discuss the application of mutagenesis-based forward genetic approaches in common animal model species: two invertebrates, nematodes (Caenorhabditis elegans) and fruit flies (Drosophila sp.); and two vertebrates, zebrafish (Danio rerio) and mice (Mus musculus), in relation to psychiatric disease. We also discuss the use of large scale genomic studies in human populations. Despite the advances using data from human populations, animal models coupled with next-generation sequencing strategies are still needed. Although with its own limitations, zebrafish possess characteristics that make them especially well-suited to forward genetic studies exploring the etiology of psychiatric disorders.

Indexed as

Mental DisordersZebrafishAnimalsCaenorhabditis elegansDisease Models, AnimalDrosophilaHumansMiceModels, AnimalAddictionC. elegansCore component behaviorsDrosophilaForward genetic screenImpulse controlMicePsychiatric diseaseZebrafish

Identifiers

PMID35124155
PMCPMC9016269
OpenAlexW4213338003

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.