ArticleEnvironmental research2022
Pesticide use and risk of systemic autoimmune diseases in the Agricultural Health Study.
Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.Current environmental health reports · 2026Review
- Pesticides, Rheumatic Diseases, and Emerging Environmental Threats: A Scoping Review of Epidemiologic and Mechanistic Evidence.Rheumatic diseases clinics of North America · 2026Article
- Understanding Sex Differences in Autoimmune Diseases: Immunologic Mechanisms.International journal of molecular sciences · 2025Review
- Herbicide-related health risks: key mechanisms and a guide to mitigation strategies.Journal of occupational medicine and toxicology (London, England) · 2025Review
- Associations between pesticide use and rheumatoid arthritis among older farmers in the Agricultural Health Study.Scientific reports · 2024Article
- Development of a predictive model for systemic lupus erythematosus incidence risk based on environmental exposure factors.Lupus science & medicine · 2024Article
- Farming Activities and Risk of Inflammatory Bowel Disease: A French Nationwide Population-based Cohort Study.Journal of Crohn's & colitis · 2024Article
- Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
- Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study.Environmental research · 2024Article
- Occupational farm work activities influence workers' indoor home microbiome.Environmental research · 2024Article
- Advances in Microfluidics Techniques for Rapid Detection of Pesticide Residues in Food.Foods (Basel, Switzerland) · 2023Review
- Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Precision agricultural robotic sprayer with real-time Tobacco recognition and spraying system based on deep learning.PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSystemic lupus erythematosus (SLE) risk has been associated with pesticide use, but evidence on specific pesticides or other agricultural exposures is lacking. We investigated history of pesticide use and risk of SLE and a related disease, Sjögren's syndrome (SS), in the Agricultural Health Study.
methodsThe study sample (N = 54,419, 52% male, enrolled in 1993-1997) included licensed pesticide applicators from North Carolina and Iowa and spouses who completed any of the follow-up questionnaires (1999-2003, 2005-2010, 2013-2015). Self-reported cases were confirmed by medical records or medication use (total: 107 incident SLE or SS, 79% female). We examined ever use of 31 pesticides and farm tasks and exposures reported at enrollment in association with SLE/SS, using Cox regression to estimate hazard ratios (HR) and 95% confidence intervals (CI), with age as the timescale and adjusting for gender, state, and correlated pesticides.
resultsIn older participants (>62 years), SLE/SS was associated with ever use of the herbicide metribuzin (HR 5.33; 95%CI 2.19, 12.96) and applying pesticides 20+ days per year (2.97; 1.20, 7.33). Inverse associations were seen for petroleum oil/distillates (0.39; 0.18, 0.87) and the insecticide carbaryl (0.56; 0.36, 0.87). SLE/SS was inversely associated with having a childhood farm residence (0.59; 0.39, 0.91), but was not associated with other farm tasks/exposures (except welding, HR 2.65; 95%CI 0.96, 7.35).
conclusionsThese findings suggest that some agricultural pesticides may be associated with higher or lower risk of SLE/SS. However, the overall risk associated with farming appears complex, involving other factors and childhood exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.