Evidence map›Paper›PMID 35123872›Full record

ArticleTrends in biochemical sciences2022

Tinker, tailor, antiviral: RNA virus inhibition by induced recombination.

Emmanuelle Pitre, Aartjan J W Te Velthuis

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in biochemical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Emmanuelle PitreDepartment of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK; Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
Aartjan J W Te VelthuisLewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ, USA. Electronic address: aj.te.velthuis@princeton.edu.

Funding

Wellcome Trust 206579/Z/17/Z
6 · The paper itself

Abstract

Nucleotide analogs can help to combat RNA virus growth by stalling the viral RNA polymerase or by introducing lethal mutations into the viral genome. Janissen and Woodman et al. have used single-molecule, sequencing, and virological methods to reveal that antiviral T-1106 provides a third mechanism of counterattack: inducing recombination.

Indexed as

Antiviral AgentsRNA VirusesGenome, ViralRecombination, GeneticRNA, ViralAntiviral AgentsRNA, Viralmagnetic tweezersrecombinationRNA polymerasetemplate switching

Identifiers

PMID35123872

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.