ArticleJournal of diabetes and its complications2022
Cardiovascular risk factor progression in adolescents and young adults with youth-onset type 2 diabetes.
Article in Journal of diabetes and its complications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Relationship between Insulin Resistance and Circulating Stem and Progenitor Cells in Newlydiagnosed Youth-onset Type 2 Diabetes.Endocrine, metabolic & immune disorders drug targets · 2026Article
- 14. Children and Adolescents: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Gestational Glucose Intolerance and Risk of Obesity in Childhood and Adolescence.The Journal of clinical endocrinology and metabolism · 2025Article
- Continuous Glucose Monitoring Use in Youth with Type 2 Diabetes: A Pilot Randomized Study.Diabetes technology & therapeutics · 2025Article
- Article
- Did smoking behavior change in adolescents and young adults with and without diabetes during the COVID-19 pandemic? A cohort study from the DPV registry.BMC pediatrics · 2025Article
- Linking Estimated Glucose Disposal Rate to Major Adverse Cardio-Cerebrovascular Events in Populations With and Without Diabetes: A Systematic Review and Meta-Analysis.Clinical medicine insights. Endocrinology and diabetes · 2025Article
- Non-Pharmacological Treatment for Cardiovascular Risk Prevention in Children and Adolescents with Obesity.Nutrients · 2024Review
- Rising tide: The global surge of type 2 diabetes in children and adolescents demands action now.World journal of diabetes · 2024Article
- Antihypertensive and Lipid-Lowering Medication Adherence in Young Adults With Youth-Onset Type 2 Diabetes.JAMA network open · 2023Observational
- Article
- Youth-Onset Type 2 Diabetes: Burden of Complications and Socioeconomic Cost.Current diabetes reports · 2023Review
- Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
aimsYouth-onset type 2 diabetes (T2D) confers a high risk of early adverse cardiovascular morbidity. We describe the cumulative incidence and prevalence of cardiovascular risk factors over time and examine relationships with diabetes progression in young adults with youth-onset T2D from the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study.
methodsLongitudinal data was used to evaluate the relationships between hypertension, LDL-C dyslipidemia, hypertriglyceridemia, and smoking with risk factors in 677 participants.
resultsBaseline mean age was 14 ± 2 years and mean follow-up 10.2 ± 4.5 years. The 14-year cumulative incidence of hypertension, LDL-C dyslipidemia, and hypertriglyceridemia was 59%, 33%, and 37% respectively. Average prevalence of reported smoking was 23%. Male sex, non-Hispanic white race/ethnicity, obesity, poor glycemic control, lower insulin sensitivity, and reduced beta-cell function were significantly associated with an unfavorable risk profile. At end of follow-up, 54% had ≥2 cardiovascular risk factors in addition to T2D.
conclusionsCardiovascular risk factor incidence and prevalence was high over a decade of follow-up in young adults with youth-onset T2D. Glucose control and management of cardiovascular risk factors is critical in youth with T2D for prevention of cardiovascular morbidity and mortality.
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