Observational studyAnnals of clinical microbiology and antimicrobials2022
Genomic insights into virulence factors affecting tissue-invasive Klebsiella pneumoniae infection.
Observational study in Annals of clinical microbiology and antimicrobials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 15 citations in OpenAlex.
- Prevalence, Virulence, and Pathogenic Mechanisms of Mastitis-AssociatedVeterinary sciences · 2026Review
- Molecular detection of hypervirulent Klebsiella pneumoniae (hvKp) in Egyptian poultry.BMC veterinary research · 2026Article
- Carriage of hypervirulent and ESBL-producingApplied and environmental microbiology · 2026Article
- [Clinical features and virulence gene distribution ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Application and evaluation of a rapid detection method based on two-dimensional PCR technology for hypervirulentFrontiers in microbiology · 2025Article
- Clinical Characteristics, Virulence Profile, and Molecular Epidemiology ofInfection and drug resistance · 2025Article
- A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks ofMicroorganisms · 2024Review
- Severe co-infection caused by difficult-to-diagnose hypermucoviscous Klebsiella pneumoniae K1-ST82 in a patient with COVID-19: a case report.BMC infectious diseases · 2024Article
- Occurrence of carbapenem-resistant hypervirulent Klebsiella pneumoniae in oysters in Egypt: a significant public health issue.Annals of clinical microbiology and antimicrobials · 2024Article
- Phenotypic and genomic characteristics of clinical IMP-producing Klebsiella spp. Isolates in China.Communications medicine · 2024Article
- Case Study and Genomic Analysis of a Hypervirulent ST25Infection and drug resistance · 2024Article
- Genetic and Functional Analysis of theMicrobiology spectrum · 2023Article
- HypervirulentInfection and drug resistance · 2023Review
- Population dynamics and characteristics ofFrontiers in microbiology · 2023Article
- Epidemiological Features ofInfection and drug resistance · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe key virulence factors responsible for hypervirulent Klebsiella pneumoniae (hvKp) infection remains elusive.
methodsWe analyzed K. pneumoniae isolates collected between 2017 and 2019 and defined hvKp as a pyogenic infection. Classical K. pneumoniae (cKp) involved a non-invasive infection or uncomplicated bacteremia. Isolates belonging to the K. pneumoniae species complex were excluded.
resultsWe analyzed 112 isolates, including 19 hvKp, 67 cKp, and 26 colonizers, using whole-genome sequencing. Population genomics revealed that the K1-sequence type (ST) 82 (O1v1) clade was distinct from that of the K1-ST23 (O1v2) clone. The virulence gene profiles also differed between K1-ST82 (aerobactin and rmpA) and K1-ST23 (aerobactin, yersiniabactin, salmochelin, colibactin, and rmpA/rmpA2). The K2 genotype was more diverse than that of K1. A neighboring subclade of K1-ST23 (comprising ST29, ST412, ST36, and ST268) showed multidrug resistance and hypervirulence potentials. Logistic-regression analysis revealed that diabetes mellitus was associated with K. pneumoniae infection (odds ratio [OR]: 4.11; 95% confidence interval [CI]: 1.14-14.8). No significant association was found between hvKp diagnosis and clinical characteristics, such as diabetes mellitus or community acquisition. However, the K1 genotype (OR: 9.02; 95% CI: 2.49-32.7; positive-likelihood ratio [LR]: 4.08), rmpA (OR: 8.26; 95% CI: 1.77-38.5; positive LR: 5.83), and aerobactin (OR: 4.59; 95% CI: 1.22-17.2; positive LR: 3.49) were substantial diagnostic predictors of hvKp.
conclusionsThe K1 genotype, rmpA, and aerobactin are prominent predictors of hvKp, suggesting that further pyogenic (metastatic) infection should be examined clinically. These findings may shed light on key hvKp virulence factors.
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