Evidence map›Paper›PMID 35123411›Full record

ArticleThe journal of headache and pain2022

Dynamic brainstem and somatosensory cortical excitability during migraine cycles.

Fu-Jung Hsiao, Wei-Ta Chen, Li-Ling Hope Pan, Hung-Yu Liu, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Gianluca Coppola, Shuu-Jiun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  6. Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Fu-Jung HsiaoBrain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wei-Ta ChenBrain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. wtchen@vghtpe.gov.tw.ORCID http://orcid.org/0000-0003-2355-3540
Li-Ling Hope PanBrain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Hung-Yu LiuSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yen-Feng WangSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Shih-Pin ChenBrain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Kuan-Lin LaiSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.
Shuu-Jiun WangBrain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. sjwang@vghtpe.gov.tw.
National Yang Ming Chiao Tung University · TWMinistry of Health and Welfare · KRSapienza University of Rome · IT

Funding

Ministry of Science and Technology, Taiwan 108-2221-E-010-004 and 109-2221-E-003-MY2Ministry of Science and Technology, Taiwan 108-2321-B-010-001, 108-2321-B-010-014-MY2, 110-2321-B-010-005, and 111-2321-B-010-004Ministry of Science and Technology, Taiwan 109-2314-B-075 -050 -MY2
6 · The paper itself

Abstract

backgroundMigraine has complex pathophysiological characteristics and episodic attacks. To decipher the cyclic neurophysiological features of migraine attacks, in this study, we compared neuronal excitability in the brainstem and primary somatosensory (S1) region between migraine phases for 30 consecutive days in two patients with episodic migraine.

methodsBoth patients underwent EEG recording of event-related potentials with the somatosensory and paired-pulse paradigms for 30 consecutive days. The migraine cycle was divided into the following phases: 24-48 h before headache onset (Pre2), within 24 h before headache onset (Pre1), during the migraine attack (Ictal), within 24 h after headache offset (Post1), and the interval of ˃48 h between the last and next headache phase (Interictal). The normalised current intensity in the brainstem and S1 and gating ratio in the S1 were recorded and examined.

resultsSix migraine cycles (three for each patient) were analysed. In both patients, the somatosensory excitability in the brainstem (peaking at 12-14 ms after stimulation) and S1 (peaking at 18-19 ms after stimulation) peaked in the Pre1 phase. The S1 inhibitory capability was higher in the Ictal phase than in the Pre1 phase.

conclusionThis study demonstrates that migraine is a cyclic excitatory disorder and that the neural substrates involved include the somatosensory system, starting in the brainstem and spanning subsequently to the S1 before the migraine occurs. Further investigations with larger sample sizes are warranted.

Indexed as

Migraine DisordersBrain StemEvoked PotentialsHumansBrainstemExcitabilityInhibitionMigraine cyclePrimary somatosensory cortex (S1)

Identifiers

PMID35123411
PMCPMC8903675
OpenAlexW4210758632

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.