Evidence map›Paper›PMID 35123407›Full record

ArticleJournal of neurodevelopmental disorders2022

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.

Siavash Fazel Darbandi, Andrew D Nelson, Emily Ling-Lin Pai, Kevin J Bender, John L R Rubenstein

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Shared and Distinct Functional Effects of Patient-SpecificThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Siavash Fazel DarbandiDepartment of Psychiatry and Behavioral Sciences, and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Andrew D NelsonWeill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Emily Ling-Lin PaiDepartment of Psychiatry and Behavioral Sciences, and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Kevin J BenderWeill Institute for Neurosciences, University of California, San Francisco, CA, USA.
John L R RubensteinDepartment of Psychiatry and Behavioral Sciences, and Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. john.rubenstein@ucsf.edu.
University of California, San Francisco · US

Funding

Genetic Studies of Cortex Structure and DevelopmentR01NS099099 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 2016 to 2025
$6.4M
GENETIC STUDIES OF CORTEX STRUCTURE AND DEVELOPMENTR01NS034661 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JOHN L. R. · 1996 to 2015
$4.6M
Convergent mechanisms for neurodevelopmental disorder genesR01MH126960 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nadav Ahituv, Kevin J Bender · 2021 to 2026
$3.5M
The function of SCN2A in neocortexR01MH125978 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BENDER, KEVIN J · 2021 to 2025
$2.0M
Cellular Mechanisms of Convergence Among Autism Spectrum Disorder GenesF32MH125536 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NELSON, ANDREW D · 2021 to 2023
$153k
NIMH NIH HHS F32 MH125536NIMH NIH HHS R01 MH125978NIMH NIH HHS R01 MH126960NINDS NIH HHS R01 NS034661NINDS NIH HHS R01 NS099099
6 · The paper itself

Abstract

backgroundTbr1 encodes a T-box transcription factor and is considered a high confidence autism spectrum disorder (ASD) gene. Tbr1 is expressed in the postmitotic excitatory neurons of the deep neocortical layers 5 and 6. Postnatally and neonatally, Tbr1 conditional mutants (CKOs) have immature dendritic spines and reduced synaptic density. However, an understanding of Tbr1's function in the adult mouse brain remains elusive.

methodsWe used conditional mutagenesis to interrogate Tbr1's function in cortical layers 5 and 6 of the adult mouse cortex.

resultsAdult Tbr1 CKO mutants have dendritic spine and synaptic deficits as well as reduced frequency of mEPSCs and mIPSCs. LiCl, a WNT signaling agonist, robustly rescues the dendritic spine maturation, synaptic defects, and excitatory and inhibitory synaptic transmission deficits.

conclusionsLiCl treatment could be used as a therapeutic approach for some cases of ASD with deficits in synaptic transmission.

Indexed as

Autism Spectrum DisorderAnimalsHumansMiceNeurogenesisNeuronsSynaptic TransmissionT-Box Domain ProteinsTranscription FactorsT-Box Domain ProteinsTBR1 protein, humanTbr1 protein, mouseTranscription FactorsAutism spectrum disorderCortexDendritic spineExcitatory neuronmPFCxSynaptic rescueSynaptic transmissionSynaptogenesisTbr1

Identifiers

PMID35123407
PMCPMC8903688
OpenAlexW4210254333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.