ArticleChild abuse & neglect2022
Multi-type childhood maltreatment exposure and substance use development from adolescence to early adulthood: A GxE study.
Article in Child abuse & neglect, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Childhood maltreatment and early-onset substance use: sex differences in the impact of various types of maltreatment and psychiatric comorbidity.BMC psychiatry · 2026Article
- Childhood maltreatment associated with adolescent peer networks: Withdrawal, avoidance, and fragmentation.Child abuse & neglect · 2024Article
- Mentalization in young patients undergoing opioid agonist treatment: Implications for clinical management.Addictive behaviors reports · 2023Article
- Factors associated with child abuse among children and adolescents in a Peruvian public hospital.Journal of medicine and life · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChildhood maltreatment types can co-occur and are associated with increased substance use during adolescence and early adulthood. There is also a strong genetic basis for substance use which interacts with environmental factors (e.g., childhood maltreatment) to influence substance use phenotype.
objectiveThis research aimed to identify childhood maltreatment sub-groups based on type and chronicity, and their association with substance use change from adolescence to early adulthood, while accounting for the influence of substance use polygenic risk (i.e., genetic risk based on the combined effects of multiple genes).
participantsWe used a sample of unrelated European-origin Americans with genetic and childhood maltreatment data (n = 2,664) from the National Longitudinal Study of Adolescent to Adult Health.
methodsLatent profile analysis was used for sub-group identification and direct and interaction effects were tested for longitudinal trajectories of substance use utilizing generalized estimating equations.
resultsThree sub-groups with co-occurring childhood maltreatment exposures were identified: a high sexual abuse sub-group, a high physical abuse sub-group, and a normative sub-group (with low maltreatment exposure). At high polygenic risk, the high physical abuse sub-group had faster increases in substance use over time. In comparison, the high sexual abuse sub-group had faster progression in substance use only at low and medium polygenic risk.
conclusionsFindings provide initial evidence for biological and environmental differences among maltreatment sub-groups on trajectories of substance use.
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