Evidence map›Paper›PMID 35123027›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022

SARS-CoV-2 transmission in opposition-controlled Northwest Syria: modeling pandemic responses during political conflict.

Manar Marzouk, Omar Alrashid Alhiraki, Ricardo Aguas, Bo Gao, Hannah Clapham, Wael Obaid, Hani Altaleb, Naser Almhawish, Hazem Rihawi, Aula Abbara and 4 more

Abstract read
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manar MarzoukSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, 117549, Singapore; Syria Research Group (SyRG), co-hosted by the Saw Swee Hock School of Public Health and London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, United Kingdom. Electronic address: manar.marzouk@visitor.nus.edu.sg.
Omar Alrashid AlhirakiBab Al-Hawa Hospital, Surgery Department, Bab Al Hawa, Idlib, Syria. Electronic address: dr.omar.alhiraki@gmail.com.
Ricardo AguasNuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7BN. Electronic address: ricardo.aguas@ndm.ox.ac.uk.
Bo GaoNuffield Department of Medicine, University of Oxford, Old Road Campus, Headington, Oxford OX3 7BN. Electronic address: bo.gao@ndm.ox.ac.uk.
Hannah ClaphamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, 117549, Singapore. Electronic address: hannah.clapham@nus.edu.sg.
Wael ObaidHealth Information System Unit in Northwest Syria, Gaziantep, Turkey. Electronic address: wael3bed@gmail.com.
Hani AltalebRelief Experts Association and Northwest Syria COVID-19 Taskforce, Gaziantep, Turkey. Electronic address: htaleb@reliefexperts.org.
Naser AlmhawishEWARN / Assistance Coordination Unit, Şehitkamil, Gaziantep, Turkey. Electronic address: naser-mhawish@hotmail.com.
Hazem RihawiAmerican Relief Coalition for Syria (ARCS), 1100 15th Street NW, Washington, DC 20005. Electronic address: rihawi.h@gmail.com.
Aula AbbaraSyria Public Health Network and Imperial College, London, United Kingdom. Electronic address: aula.abbara@gmail.com.
Yazan DouedariSyria Research Group (SyRG), co-hosted by the Saw Swee Hock School of Public Health and London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, United Kingdom. Electronic address: Yazan.Douedari@lshtm.ac.uk.
Mahmoud HaririHealth Information System Unit in Northwest Syria, Gaziantep, Turkey; Health Information System Unit in Northwest Syria and Northwest Syria COVID-19 Taskforce, Gaziantep, Turkey. Electronic address: m.hariri@ihd-sy.org.
Natasha HowardSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, 117549, Singapore; Syria Research Group (SyRG), co-hosted by the Saw Swee Hock School of Public Health and London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, United Kingdom. Electronic address: natasha.howard@nus.edu.sg.
CoMo Consortium

Funding

Medical Research Council MR/S013121/1
6 · The paper itself

Abstract

introductionTen years of conflict has displaced more than half of Northwest Syria's (NWS) population and decimated the health system, water and sanitation, and public health infrastructure vital for infectious disease control. The first NWS COVID-19 case was declared on July 9, 2020, but impact estimations in this region are minimal. With the rollout of vaccination and emergence of the B.1.617.2 (Delta) variant, we aimed to estimate the COVID-19 trajectory in NWS and the potential effects of vaccine coverage and hospital occupancy.

methodsWe conducted a mixed-method study, primarily including modeling projections of COVID-19 transmission scenarios with vaccination strategies using an age-structured, compartmental susceptible-exposed-infectious-recovered (SEIR) model, supported by data from 20 semi-structured interviews with frontline health workers to help contextualize interpretation of modeling results.

resultsModeling suggested that existing low stringency non-pharmaceutical interventions (NPIs) minimally affected COVID-19 transmission. Maintaining existing NPIs after the Delta variant introduction is predicted to result in a second COVID-19 wave, overwhelming hospital capacity and resulting in a fourfold increased death toll. Simulations with up to 60% vaccination coverage by June 2022 predict that a second wave is not preventable with current NPIs. However, 60% vaccination coverage by June 2022 combined with 50% coverage of mask-wearing and handwashing should reduce the number of hospital beds and ventilators needed below current capacity levels. In the worst-case scenario of a more transmissible and lethal variant emerging by January 2022, the third wave is predicted.

conclusionTotal COVID-19 attributable deaths are expected to remain relatively low owing largely to a young population. Given the negative socioeconomic consequences of restrictive NPIs, such as border or school closures for an already deeply challenged population and their relative ineffectiveness in this context, policymakers and international partners should instead focus on increasing COVID-19 vaccination coverage as rapidly as possible and encouraging mask-wearing.

Indexed as

COVID-19SARS-CoV-2COVID-19 VaccinesHumansPandemicsSyriaCOVID-19 VaccinesCOVID-19ModelingNon-pharmaceutical interventionsSyriaVaccination

Identifiers

PMID35123027
PMCPMC8808433

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.