ArticleThe Science of the total environment2022
Ambient air pollution exposure and increasing depressive symptoms in older women: The mediating role of the prefrontal cortex and insula.
Abstract read
In one paragraph
Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- PMiScience · 2026Review
- The Relationship between Air Pollution Exposure, Genetic Liability for Schizophrenia, and Brain Outcomes in the ABCD Study.Schizophrenia bulletin · 2026Article
- Synergistic air pollution exposure elevates depression risk: A cohort study.Environmental science and ecotechnology · 2025Article
- Pulmonary Flora-Derived Lipopolysaccharide Mediates Lung-Brain Axis through Activating Microglia Involved in Polystyrene Microplastic-Induced Cognitive Dysfunction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Robust differential gene expression patterns in the prefrontal cortex of male mice exposed to an occupationally relevant dose of laboratory-generated wildfire smoke.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Climate Change and Aging: Implications for Psychiatric Care.Current psychiatry reports · 2024Review
- How does the macroenvironment influence brain and behaviour-a review of current status and future perspectives.Molecular psychiatry · 2024Review
- Influence of Mild Chronic Stress and Social Isolation on Acute Ozone-Induced Alterations in Stress Biomarkers and Brain-Region-Specific Gene Expression in Male Wistar-Kyoto Rats.Antioxidants (Basel, Switzerland) · 2023Article
- How does the macroenvironment influence brain and behaviour - a review of current status and future perspectives.medRxiv : the preprint server for health sciences · 2023Article
- Associations Between Ambient Air Pollution and Cognitive Abilities from Midlife to Early Old Age: Modification by APOE Genotype.Journal of Alzheimer's disease : JAD · 2023Article
- Article
- Common Fatal Neurodegenerative Diseases Revisited: Beyond Age, Comorbidities, and Devastating Terminal Neuropathology There Is Hope With Prevention.Frontiers in neurology · 2022Article
- Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: a perspective.Inhalation toxicologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Andrew J PetkusUniversity of Southern California, Department of Neurology, 1520 San Pablo St. Suite 3000, Los Angeles, CA 90033, United States.
Susan M ResnickNational Institute on Aging, Laboratory of Behavioral Neuroscience, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, United States.
Xinhui WangUniversity of Southern California, Department of Neurology, 1520 San Pablo St. Suite 3000, Los Angeles, CA 90033, United States.
Daniel P BeaversSticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, One Medical Center Blvd, Winston-Salem, NC 27157, United States of American.
Mark A EspelandSticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, One Medical Center Blvd, Winston-Salem, NC 27157, United States of American.
Margaret GatzUniversity of Southern California, Center for Economic and Social Research, 635 Downey Way, Los Angeles, CA 90089-3332, United States of America.
Tara GruenewaldChapman University, Department of Psychology, 1 University Dr., Orange, CA 92866, United States of America.
Joshua MillsteinUniversity of Southern California, Department of Population and Public Health Sciences, 2001 North Soto Street, Los Angeles, CA 90033, United States of America.
Helena C ChuiUniversity of Southern California, Department of Neurology, 1520 San Pablo St. Suite 3000, Los Angeles, CA 90033, United States.
Joel D KaufmanUniversity of Washington, Department of Environmental and Occupational Health Sciences, 1959 NE Pacific St., Box 257230, Seattle, WA 98105, United States of America.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, United States of America.
Gregory A WelleniusBoston University, Boston, School of Public Health, Department of Environmental Health, 715 Albany St., Boston, MA 02118, United States of America.
Eric A WhitselUniversity of North Carolina, Gillings School of Public Health, Department of Epidemiology, 123 W. Franklin St., Suite 410, Chapel Hill, NC 27516-8050, United States of America.
Keith WidamanUniversity of California, Riverside, Graduate School of Education, 900 University Ave, Riverside, CA 9251, United States of America.
Diana YounanUniversity of Southern California, Department of Population and Public Health Sciences, 2001 North Soto Street, Los Angeles, CA 90033, United States of America.
Jiu-Chiuan ChenUniversity of Southern California, Department of Neurology, 1520 San Pablo St. Suite 3000, Los Angeles, CA 90033, United States; University of Southern California, Department of Population and Public Health Sciences, 2001 North Soto Street, Los Angeles, CA 90033, United States of America. Electronic address: jcchen@usc.edu.
Funding
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4MXENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8MWake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3MUrban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FRANZ, CAROL ELAINE · 2018 to 2022
$11.5MAlzheimer's Disease & Related Dementias: Geography, Environments, and MechanismsRF1AG054068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2016 to 2016
$4.1MEnvironmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2MEnvironmental Determinants of Cognitive Aging in the WHI Memory StudyR01AG033078 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2011 to 2014
$2.6MAir pollution, the social environment, and Alzheimer's disease: Risk and resilience in the Ginkgo Evaluation Memory StudyRF1AG057033 · NIA · UNIVERSITY OF WASHINGTON · PI FITZPATRICK, ANNETTE L., KAUFMAN, JOEL DANIEL · 2017 to 2017
$2.3MWomen's Health Initiative Suite of Studies - Extension StudyZIAAG000190 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2009 to 2024
$1.5MEPA RD838300NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIA NIH HHS N01 AG012106NIA NIH HHS P01 AG055367NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072947NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG033078NIA NIH HHS RF1 AG054068NIA NIH HHS RF1 AG057033NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES025888WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
Exposures to fine particulate matter (PM
Indexed as
Air PollutantsAir PollutionAgedAged, 80 and overCross-Sectional StudiesDepressionEnvironmental ExposureFemaleHumansNitrogen DioxideParticulate MatterPrefrontal CortexProspective StudiesAir PollutantsNitrogen DioxideParticulate MatterAir pollutionBrain agingDepressionStructural magnetic resonance imaging
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.