Evidence map›Paper›PMID 35122662›Full record

ArticleJournal of the American Geriatrics Society2022

Incidence of potentially disruptive medical and social events in older adults with and without dementia.

Lauren J Hunt, R Sean Morrison, Siqi Gan, Edie Espejo, Katherine A Ornstein, W John Boscardin, Alexander K Smith

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lauren J HuntDepartment of Physiological Nursing, University of California, San Francisco, California, USA.ORCID 0000-0002-2731-2173
R Sean MorrisonDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Siqi GanDivision of Geriatrics, Department of Medicine, University of California, San Francisco, California, USA.
Edie EspejoDivision of Geriatrics, Department of Medicine, University of California, San Francisco, California, USA.
Katherine A OrnsteinDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
W John BoscardinDivision of Geriatrics, Department of Medicine, University of California, San Francisco, California, USA.
Alexander K SmithJames J. Peters VA Medical Center, Bronx, New York, USA.
University of California, San Francisco · USIcahn School of Medicine at Mount Sinai · USJames J. Peters VA Medical Center · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALBERT L SIU · 2010 to 2026
$21.9M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
Unnecessary and Harmful Medication Use in Older Adults with DementiaP01AG066605 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI W. JOHN BOSCARDIN · 2020 to 2026
$17.7M
Advanced-Stage Development of a Geriatric Palliative Care Research InfrastructureR33AG065726 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALDRIDGE, MELISSA DIANE, MORRISON, R. SEAN · 2020 to 2024
$3.4M
Mentoring Researchers in Prognosis Research in Alzheimer’s Disease and Related DementiasK24AG068312 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2020 to 2026
$1.2M
Hospice Use in Older Adults with Alzheimer's Disease and Related Dementias: Patterns, Policies, and Caregiver ExperiencesK76AG074924 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, LAUREN · 2021 to 2025
$1.1M
NCATS NIH HHS KL2 TR001870NIA NIH HHS K24 AG068312NIA NIH HHS K76 AG074924NIA NIH HHS P01 AG066605NIA NIH HHS P30 AG028741NIA NIH HHS P30 AG044281NIA NIH HHS R33 AG065726NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

backgroundPotentially disruptive medical, surgical, and social events-such as pneumonia, hip fracture, and widowhood-may accelerate the trajectory of decline and impact caregiving needs in older adults, especially among people with dementia (PWD). Prior research has focused primarily on nursing home residents with dementia. We sought to assess the incidence of potentially disruptive events in community-dwelling people with and without dementia.

methodsRetrospective cohort study of participants aged 65+ enrolled in the Health and Retirement Study between 2010 and 2018 (n = 9346), including a subset who were married-partnered at baseline (n = 5105). Dementia was defined with a previously validated algorithm. We calculated age-adjusted and gender-stratified incidence per 1000 person-years and incidence rate ratios of: 1) hospitalization for pneumonia, 2) hip fracture, and 3) widowhood in people with and without dementia.

resultsPWD (n = 596) were older (mean age 84 vs. 75) and a higher proportion were female (67% vs. 57%) than people without dementia (PWoD) (n = 8750). Age-adjusted incidence rates (per 1000 person-years) of pneumonia were higher in PWD (113.1; 95% CI 94.3, 131.9) compared to PWoD (62.1; 95% CI 54.7, 69.5), as were hip fractures (12.3; 95% CI 9.1, 15.6 for PWD compared to 8.1; 95% CI 6.9, 9.2 in PWoD). Point estimates of widowhood incidence were slightly higher for PWD (25.3; 95% CI 20.1, 30.5) compared to PWoD (21.9; 95% CI 20.3, 23.5), but differences were not statistically significant. The association of dementia with hip fracture-but not pneumonia or widowhood-was modified by gender (male incidence rate ratio [IRR] 2.24, 95% CI 1.34, 3.75 versus female IRR 1.31 95% CI 0.92,1.86); interaction term p = 0.02).

conclusionsCompared to PWoD, community-dwelling PWD had higher rates of pneumonia and hip fracture, but not widowhood. Knowing how often PWD experience these events can aid in anticipatory guidance and care planning for this growing population.

Indexed as

DementiaHip FracturesPneumoniaAgedAged, 80 and overFemaleHumansIncidenceMaleRetrospective Studiesdementiahip fracturepneumoniawidowhood

Identifiers

PMID35122662
PMCPMC9106866
OpenAlexW4210563245

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.