Evidence map›Paper›PMID 35122611›Full record

ArticleCurrent medical science2022

Optimal Formula of Angelica sinensis Ameliorates Memory Deficits in β-amyloid Protein-induced Alzheimer's Disease Rat Model.

Hu-Ping Wang, Hong-Yan Wu, Chun-Lin Ma, Qing-Tao Zeng, Kai-Min Zhu, Shu-Mei Cui, Hai-Long Li, Guo-Tai Wu, Zhi-Wei Wu, Jian-Zheng He

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Current medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Myeloperoxidase as a therapeutic target for oxidative damage in Alzheimer's disease.Journal of enzyme inhibition and medicinal chemistry · 2025
    Review
  3. Article
  4. Frontiers in neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hu-Ping WangBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China. whupboy@126.com.
Hong-Yan WuBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Chun-Lin MaBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Qing-Tao ZengBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Kai-Min ZhuBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Shu-Mei CuiBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Hai-Long LiClinical Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Guo-Tai WuPharmacy College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Zhi-Wei WuBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Jian-Zheng HeBasic Medicine College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Gansu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAngelica (A.) sinensis is used as a traditional medical herb for the treatment of neurodegeneration, aging, and inflammation in Asia. A. sinensis optimal formula (AOF) is the best combination in A. sinensis that has been screened to rescue the cognitive ability in β-amyloid peptide (Aβ

methodsMale Wistar rats were infused with Aβ

resultsThe results showed that AOF administration significantly ameliorated Aβ

conclusionThese experimental findings illustrate that AOF prevents the decrease in cognitive function and Aβ deposits in Aβ

Indexed as

Angelica sinensisAlzheimer DiseaseAmyloid beta-PeptidesAnimalsDisease Models, AnimalMaleMemory DisordersNeuroinflammatory DiseasesNootropic AgentsOxidative StressPlant PreparationsRatsRats, WistarAmyloid beta-PeptidesNootropic AgentsPlant PreparationsAlzheimer’s diseaseamyloid β aggregationneuroinflammationoptimal formula of Angelica sinensisoxidative stress

Identifiers

PMID35122611
OpenAlexW4210723637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.