ArticleBiogerontology2022
Mapping sex differences in the effects of protein and carbohydrates on lifespan and reproduction in Drosophila melanogaster: is measuring nutrient intake essential?
Article in Biogerontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Mating-dependent lifespan cost of sterol depletion in maleProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mating regulates growth, metabolism, and digestive efficiency in the femaleProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- The role of genetic variation in shaping phenotypic responses to diet in aging Drosophila melanogaster.Heredity · 2025Article
- Macronutrient balance dictates lifespan and reproduction in a beetle, Tenebrio molitor.The Journal of experimental biology · 2025Article
- Nutritional Trade-Offs inBiology · 2025Article
- Mating reconciles fitness and fecundity by switching diet preference in flies.Nature communications · 2024Article
- Effect of Lactational Low-Protein Diet on Skeletal Muscle during Adulthood and Ageing in Male and Female Mouse Offspring.Nutrients · 2024Article
- Optimum ratio of dietary protein and carbohydrate that maximises lifespan is shared among related insect species.Aging cell · 2024Article
- Article
- Temperature- and Diet-Induced Plasticity of Growth and Digestive Enzymes Activity in Spongy Moth Larvae.Biomolecules · 2023Article
- Nutrigonometry IV: Thales' theorem to measure the rules of dietary compromise in animals.Scientific reports · 2023Article
- A protein restricted diet induces a stable increased fat storage phenotype in flies.Toxicology reports · 2023Article
- Selection on female reproductive schedules in the marula fly,Frontiers in insect science · 2023Article
- Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females.Scientific reports · 2022Article
- Parental dietary protein effects on offspring viability in insects and other oviparous invertebrates: a meta-analysis.Current research in insect science · 2022Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how diet affects reproduction and survival is a central aim in evolutionary biology. Although this relationship is likely to differ between the sexes, we lack data relating diet to male reproductive traits. One exception to this general pattern is Drosophila melanogaster, where male dietary intake was quantified using the CApillary FEeder (CAFE) method. However, CAFE feeding reduces D. melanogaster survival and reproduction, so may distort diet-fitness outcomes. Here, we use the Geometric Framework of Nutrition to create nutrient landscapes that map sex-specific relationships between protein, carbohydrate, lifespan and reproduction in D. melanogaster. Rather than creating landscapes with consumption data, we map traits onto the nutrient composition of forty agar-based diets, generating broad coverage of nutrient space. We find that male and female lifespan was maximised on low protein, high carbohydrate blends (~ 1
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