ArticleActa neurochirurgica2022
Delayed development of cerebral atrophy after cerebral hyperperfusion following arterial bypass for adult patients with ischemic moyamoya disease: supplementary analysis of a 5-year prospective cohort.
Article in Acta neurochirurgica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease.PloS one · 2026Article
- Symptomatic cerebral hyperperfusion after occipital artery-posterior cerebral artery bypass in a patient with moyamoya disease: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Inhalational versus intravenous anesthetic for cerebrovascular accident outcomes after surgical revascularization for adult moyamoya disease.BMC anesthesiology · 2025Article
- Clinical Features and Treatment Outcomes in Patients in Their Twenties with Ischemic Moyamoya Disease.Cerebrovascular diseases extra · 2024Article
- Cognitive dysfunction in Moyamoya disease: latest developments and future directions.Frontiers in human neuroscience · 2024Review
- Advances in differential diagnosis of cerebrovascular diseases in magnetic resonance imaging: a narrative review.Quantitative imaging in medicine and surgery · 2023Review
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10 authors at 1 institution in 1 country.
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Abstract
backgroundAdult patients with moyamoya disease (MMD) occasionally exhibit cerebral hyperperfusion after arterial bypass surgery, leading to persistent cognitive decline. The present supplementary analysis of a prospective 5-year cohort study aimed to determine whether cerebral hyperperfusion after arterial bypass surgery for adult patients with misery perfusion due to ischemic MMD causes cerebral atrophy, and whether the development of cerebral atrophy is related to persistent cognitive decline.
methodsIn total, 31 patients who underwent arterial bypass surgery also underwent fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) and neuropsychological testing before surgery and at the end of a 5-year follow-up. The development of cerebral hyperperfusion and hyperperfusion syndrome after surgery was defined based on brain perfusion single-photon emission computed tomography (SPECT) findings and clinical symptoms. Univariate and multivariate logistic regression analyses of factors related to the development of cerebral atrophy on FLAIR MRI or cognitive decline on neuropsychological testing at the end of the 5-year follow-up were performed.
resultsEleven patients (35%) developed cerebral atrophy in the frontal lobe where the superficial temporal artery was anastomosed. Cerebral hyperperfusion on brain perfusion SPECT (odds ratio [OR], 50.6; p = 0.0008) or cerebral hyperperfusion syndrome (OR, 41.8; p = 0.0026) was independently associated with the development of cerebral atrophy, and cerebral atrophy development was significantly associated with cognitive decline (OR, 47.7; p = 0.0010).
conclusionsCerebral hyperperfusion after arterial bypass surgery for adult patients with misery perfusion due to ischemic MMD can cause cerebral atrophy related to persistent cognitive decline.
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