Evidence map›Paper›PMID 35122516›Full record

ReviewParasitology research2022

The evolving story of Borrelia burgdorferi sensu lato transmission in Europe.

Antje Steinbrink, Katharina Brugger, Gabriele Margos, Peter Kraiczy, Sven Klimpel

Open access · hybridAbstract readReview
In one paragraph

Review in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Review
  3. Resistance ofPathogens (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Lyme borreliosis.Nature reviews. Disease primers · 2026
    Review
  8. Article
  9. [Unilateral painful nodules along the ulna].Dermatologie (Heidelberg, Germany) · 2026
    Article
  10. Review
  11. Prevalence ofPathogens (Basel, Switzerland) · 2025
    Article
  12. Article
  13. Animals : an open access journal from MDPI · 2025
    Article
  14. Case report of ischemic stroke in a child secondary to neuroborreliosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Antje SteinbrinkInstitute for Insect Biotechnology, Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 26, 35392, Giessen, Germany. antje.steinbrink@agrar.uni-giessen.de.
Katharina BruggerUnit for Veterinary Public Health and Epidemiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210, Vienna, Austria.
Gabriele MargosGerman National Reference Centre for Borrelia, Bavarian Health and Food Safety Authority Branch, Veterinärstraße 2, 85764, Oberschleißheim, Germany.
Peter KraiczyInstitute of Medical Microbiology and Infection Control, University Hospital of Frankfurt, Goethe University Frankfurt, Paul-Ehrlich-Straße 40, 60596, Frankfurt am Main, Germany.
Sven KlimpelLOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Senckenberganlage 25, 60325, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-9191-3256
Goethe University Frankfurt · DEJustus-Liebig-Universität Gießen · DEUniversity of Veterinary Medicine Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beside mosquitoes, ticks are well-known vectors of different human pathogens. In the Northern Hemisphere, Lyme borreliosis (Eurasia, LB) or Lyme disease (North America, LD) is the most commonly occurring vector-borne infectious disease caused by bacteria of the genus Borrelia which are transmitted by hard ticks of the genus Ixodes. The reported incidence of LB in Europe is about 22.6 cases per 100,000 inhabitants annually with a broad range depending on the geographical area analyzed. However, the epidemiological data are largely incomplete, because LB is not notifiable in all European countries. Furthermore, not only differ reporting procedures between countries, there is also variation in case definitions and diagnostic procedures. Lyme borreliosis is caused by several species of the Borrelia (B.) burgdorferi sensu lato (s.l.) complex which are maintained in complex networks including ixodid ticks and different reservoir hosts. Vector and host influence each other and are affected by multiple factors including climate that have a major impact on their habitats and ecology. To classify factors that influence the risk of transmission of B. burgdorferi s.l. to their different vertebrate hosts as well as to humans, we briefly summarize the current knowledge about the pathogens including their astonishing ability to overcome various host immune responses, regarding the main vector in Europe Ixodes ricinus, and the disease caused by borreliae. The research shows, that a higher standardization of case definition, diagnostic procedures, and standardized, long-term surveillance systems across Europe is necessary to improve clinical and epidemiological data.

Indexed as

Borrelia burgdorferiIxodesLyme DiseaseAnimalsEuropeHumansMosquito VectorsBorreliaIxodesLyme borreliosisLyme diseaseSpirochetesTickTick-borne diseases

Identifiers

PMID35122516
PMCPMC8816687
OpenAlexW4210498702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.