Evidence map›Paper›PMID 35122514›Full record

ArticleArchives of toxicology2022

Urolithin A attenuates arsenic-induced gut barrier dysfunction.

Sweta Ghosh, Mayukh Banerjee, Bodduluri Haribabu, Venkatakrishna Rao Jala

Open access · greenAbstract read
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sweta GhoshDepartment of Microbiology and Immunology, UofL Health-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, 505 South Hancock Street # 323, Louisville, KY, 40202, USA.
Mayukh BanerjeeDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Bodduluri HaribabuDepartment of Microbiology and Immunology, UofL Health-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, 505 South Hancock Street # 323, Louisville, KY, 40202, USA.
Venkatakrishna Rao JalaDepartment of Microbiology and Immunology, UofL Health-Brown Cancer Center, Center for Microbiomics, Inflammation and Pathogenicity, University of Louisville, 505 South Hancock Street # 323, Louisville, KY, 40202, USA. jvrao001@louisville.edu.ORCID 0000-0002-4206-7305
University of Louisville · US

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative IntravaginalP20GM125504 · NIGMS · UNIVERSITY OF LOUISVILLE · PI James Tristan Collins · 2018 to 2026
$24.4M
PROJ 12: STEM CELL-BASED VACCINE FOR CANCER PROPHYLAXISP20RR018733 · NCRR · UNIVERSITY OF LOUISVILLE · PI TRENT, JOHN O · 2003 to 2011
$18.9M
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI J CHRISTOPHER STATES · 2020 to 2026
$10.0M
Role of urolithin A in progression of alcohol-associated liver diseaseR21AA030638 · NIAAA · UNIVERSITY OF LOUISVILLE · PI JALA, VENKATAKRISHNA RAO · 2023 to 2024
$411k
PQ-10: Microbial metabolite, Urolithin A is a potent immunomodulator and chemosensitizing adjuvant in treating colon cancer.R21CA216090 · NCI · UNIVERSITY OF LOUISVILLE · PI JALA, VENKATAKRISHNA RAO · 2017 to 2018
$368k
CCR2 mediated inflammation and gut microbiota in promoting intestinal cancerR21CA191683 · NCI · UNIVERSITY OF LOUISVILLE · PI JALA, VENKATAKRISHNA RAO · 2015 to 2016
$359k
NCI NIH HHS CA191683NCI NIH HHS R21 CA191683NCI NIH HHS R21 CA216090NCRR NIH HHS P20 RR018733NIAAA NIH HHS R21 AA030638NIEHS NIH HHS P30 ES030283NIEHS NIH HHS P30ES030283NIGMS NIH HHS P20 GM125504NIGMS NIH HHS P20GM125504-01
6 · The paper itself

Abstract

Environmental chemicals such as inorganic arsenic (iAs) significantly contribute to redox toxicity in the human body by enhancing oxidative stress. Imbalanced oxidative stress rapidly interferes with gut homeostasis and affects variety of cellular processes such as proliferation, apoptosis, and maintenance of intestinal barrier integrity. It has been shown that gut microbiota are essential to protect against iAs

Indexed as

ArsenicArsenicalsGastrointestinal MicrobiomeColonCoumarinsHumansIntestinal Mucosa3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneArsenicArsenicalsCoumarinsArsenicGut barrier functionMicrobial metabolitesMicrobiotaOxidative stressUrolithin A

Identifiers

PMID35122514
PMCPMC10867785
OpenAlexW4210530680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.