Evidence map›Paper›PMID 35122408›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Metastable Iron Sulfides Gram-Dependently Counteract Resistant Gardnerella Vaginalis for Bacterial Vaginosis Treatment.

Ling Fang, Ruonan Ma, Xuejiao J Gao, Lei Chen, Yuan Liu, Yanwu Huo, Taotao Wei, Xiaonan Wang, Qian Wang, Haojue Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Comprehensive wound healing using ETN@FeJournal of nanobiotechnology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Designing Single-Atom Active Sites on spAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Ling FangCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Ruonan MaCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Xuejiao J GaoCollege of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi, 330022, China.
Lei ChenCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Yuan LiuJoint Laboratory of Nanozymes in Zhengzhou University, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Yanwu HuoNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Taotao WeiNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Xiaonan WangCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Qian WangCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Haojue WangXishan People's Hospital of Wuxi City, Wuxi, Jiangsu, 214105, China.
Chengjun CuiXishan People's Hospital of Wuxi City, Wuxi, Jiangsu, 214105, China.
Qifeng ShiXishan People's Hospital of Wuxi City, Wuxi, Jiangsu, 214105, China.
Jing JiangCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Lizeng GaoCAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.ORCID 0000-0003-0265-4027
Chinese Academy of Sciences · CNWuxi People's Hospital · CNJiangxi Normal University · CNZhengzhou University · CN

Funding

National Key R&D Program of China 2019YFA0709200National Natural Science Foundation of China 81930050National Natural Science Foundation of China (NSFC) Foundation of Innovative Research Group 22121003Wuxi Municipal Health Commission was approved M202007Wuxi Science and Technology Plan Project N2020×018
6 · The paper itself

Abstract

Bacterial vaginosis (BV) is the most common vaginal infection found in women in the world. Due to increasing drug-resistance of virulent pathogen such as Gardnerella vaginalis (G. vaginalis), more than half of BV patients suffer recurrence after antibotics treatment. Here, metastable iron sulfides (mFeS) act in a Gram-dependent manner to kill bacteria, with the ability to counteract resistant G. vaginalis for BV treatment. With screening of iron sulfide minerals, metastable Fe

Indexed as

Gardnerella vaginalisVaginosis, BacterialAnimalsBiofilmsFemaleFerrous CompoundsHumansMetronidazoleMiceFerrous Compoundsferrous sulfideMetronidazolebacterial vaginosisGram-dependentmetastable iron sulfidepolysulfide speciesresistant Gardnerella vaginalis

Identifiers

PMID35122408
PMCPMC8981900
OpenAlexW4210389701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.