ArticleInternational ophthalmology2022
Optical coherence tomography angiography in healthy children: normative data and age-related changes in microvascular structure of the optic disk and macula.
Article in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Age-Related Differences in Optical Coherence Tomography and Optical Coherence Tomography Angiography Parameters Between Healthy Children and Adults: A Comparative Analysis in a Caucasian Population.Journal of personalized medicine · 2025Article
- Normative Optical Coherence Tomography Angiography Metrics of Macular Vessel Density and Foveal Avascular Zone in Healthy Children.Journal of clinical medicine · 2025Article
- AI-Based Ocular Age Estimation from Combined OCT and OCTA Metrics: Decade-Stratified Normative Modelling in Healthy Eyes - a Pilot Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Papillary and peripapillary vascular densities and corresponding correlation with peripapillary retinal thicknesses using optical coherence tomography angiography in healthy children and adolescents.Scientific reports · 2024Article
- OCT-Angiography Findings in Children with Anisometropic Amblyopia.Children (Basel, Switzerland) · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
purposeTo determine normative data and reference ranges according to age groups by measuring the foveal avascular zone (FAZ), superficial capillary plexus vascular density (SCP-VD), deep capillary plexus vascular density (DVP-VD), radial peripapillary capillary plexus vessel density (RPC-VD), and peripapillary retinal nerve fiber layer (ppRNFL) in healthy children and to determine the age and sex-related changes of these values.
methodsThis prospective study included data from 370 eyes of 370 healthy children (202 girls, 168 boys) aged 7-18 years. Participants were divided into four groups according to their age. Optical coherence tomography angiography (OCTA) measurements were taken using AngioVue (Avanti; Optivue).
resultsNo statistically significant difference was observed in terms of FAZ, SCP-VD, DCP-VD, RPC-VD, and ppRNFL thickness values according to the age groups (except the RPC-VD superior) (p > 0.05 for all). VDs in all deep parafoveal regions in groups 1 and 2 were higher in girls. While FAZ values were higher in girls in all age groups (statistically significant in groups 1, 3, and 4), ad SPD and DPD values were higher in boys in all age groups (statistically significant in group 1 and 2 for SPD, and group 1 and 3 for DPD).
conclusionsWe report normal reference ranges for macula and disk vessel density and ppRNFL parameters in healthy children aged 7-18 years using OCTA. These normative values could be useful in diagnosing retina and optic disk disease early in childhood.
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