Evidence map›Paper›PMID 35122129›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

A comprehensive analysis of intratumor microbiome in head and neck squamous cell carcinoma.

Yangyang Wang, Yi Wang, Jihan Wang

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

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22citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Yangyang WangSchool of Electronics and Information, Northwestern Polytechnical University, Xi'an, China.
Yi WangSchool of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, China.
Jihan WangInstitute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, China. jihanwang@nwpu.edu.cn.ORCID http://orcid.org/0000-0003-1143-363X

Funding

Fundamental Research Funds for the Central Universities of Northwestern Polytechnical University G2020KY0516Shaanxi Provincial Key Research and Development Program 2021SF-030
6 · The paper itself

Abstract

purposeHuman microbiome has been considered as the second genome of our body. The intratissue/intratumor microbiome analysis is a relatively new field and deserves more attention. In this study, we conducted a comprehensive analysis of microbiome signatures of head and neck squamous cell carcinoma (HNSC).

methodsThe intratumor microbiome profiling and clinicopathological information about a total of 177 HNSC samples, including 155 tumors and 22 adjacent normal tissues, were obtained from The Cancer Microbiome Atlas (TCMA) and The Cancer Genome Atlas (TCGA) databases. We identified the microbes that differed between tumors and normal tissues, and assessed their utility values as diagnostic biomarkers. The microbiome signatures under different conditions of clinicopathological parameters were also analyzed.

resultsThe intratissue microbiome profiles differed between tumor and normal samples of HNSC. The composition of four, six, and six microbes changed in tumors compared to normal tissues at the phylum, order, and genus levels, respectively (P < 0.05). Eight of the differential microbes performed well in distinguishing tumors from normal tissues (AUC > 0.7, P ≤ 0.001). The microbiome signature was found to be associated with tumor clinicopathological characteristics such as host-gender, host-age, tumor stage, and neoplasm histologic grade.

conclusionOverall, our results revealed an intratissue microbiome signature of HNSC. We concluded that the intratumor microbiome signature may also reflect human biology in both healthy and disease status, and provide novel perspective for microbiota research about their roles in tumors.

Indexed as

Head and Neck NeoplasmsMicrobiotaBiomarkers, TumorHumansPrognosisSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorHead and neck squamous cell carcinomaIntratumor microbiomeThe Cancer Genome AtlasThe Cancer Microbiome Atlas

Identifiers

PMID35122129

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.